Equity Instruments and Transactions (Details) - USD ($) $ / shares in Units, $ in Thousands			1 Months Ended	12 Months Ended
	Apr. 28, 2020	Feb. 21, 2020	Feb. 29, 2020	Dec. 31, 2022	Aug. 31, 2022	Dec. 31, 2021
Class of Stock [Line Items]
Ordinary shares, shares authorized (in shares)				500,000,000		500,000,000
Ordinary shares, nominal value (in usd per share)				$ 0.01		$ 0.01
Ordinary shares, shares issued (in shares)				62,878,000		58,620,000
Ordinary shares, shares outstanding (in shares)				62,878,000		58,620,000
Preferred shares, shares authorized (in shares)				50,000,000		50,000,000
Preferred shares, nominal value (in usd per share)				$ 0.01		$ 0.01
Preferred shares, shares issued (in shares)				488,000		488,000
Preferred shares, shares outstanding (in shares)				488,000		488,000
Prepaid expenses and other current assets				$ 2,096		$ 32,826
Issuance of common stock under at-the-market offering program, net of issuance costs				25,318
Maximum threshold percentage for trigger of convertible preferred stock		9.99%
Issuance costs recorded as a reduction to additional paid-in capital				45
2020 Shelf Registration Statement
Class of Stock [Line Items]
Ordinary shares, nominal value (in usd per share)			$ 0.01
Preferred shares, nominal value (in usd per share)			$ 0.01
Maximum aggregate offering price of securities under shelf registration			$ 250
Maximum aggregate offering price of ADSs under shelf registration			$ 50
Sales agent commission, as a percent of aggregate gross sales proceeds			3.00%
Transaction costs			$ 428
2022 Shelf Registration Statement
Class of Stock [Line Items]
Maximum aggregate offering price of securities under shelf registration					$ 500
Maximum aggregate offering price of ADSs under shelf registration					$ 100
Securities Purchase Agreement
Class of Stock [Line Items]
Issuance of common stock under at-the-market offering program, net of issuance costs		$ 65,000
Proceeds from issuance of shares off the at-the-market offering program		$ 60,570
Securities Purchase Agreement | American Depositary Receipts
Class of Stock [Line Items]
Stock issued during period, new issues (in shares)		8,680,000
Securities Purchase Agreement | Series A Preferred Stock
Class of Stock [Line Items]
Stock issued during period, new issues (in shares)		488,000
Shares issued, price per share (in dollars per share)		$ 7.09
Public Offering | American Depositary Shares
Class of Stock [Line Items]
Public offering, shares issued (in shares)	11,630,000
Net proceeds from public offering	$ 116,924
Public offering, price per share (in dollars per share)	$ 10.75
Public offering, proceeds	$ 125,000
At-The-Market Offering Program
Class of Stock [Line Items]
Remaining authorized aggregate offering price under shelf registration				$ 123,899
At-The-Market Offering Program | American Depositary Shares
Class of Stock [Line Items]
Public offering, shares issued (in shares)				3,588,000
Net proceeds from public offering				$ 25,318
Additional paid-in capital
Class of Stock [Line Items]
Issuance of common stock under at-the-market offering program, net of issuance costs				25,282
Issuance costs recorded as a reduction to additional paid-in capital		$ 4,430		45
Additional paid-in capital | 2020 Shelf Registration Statement
Class of Stock [Line Items]
Prepaid expenses and other current assets				169
Additional paid-in capital | 2022 Shelf Registration Statement
Class of Stock [Line Items]
Prepaid expenses and other current assets				$ 192