Income Taxes - Reconciliation of Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Income tax provision (benefit) - at statutory tax rate	$ (13,916)	$ (11,642)
Differences in international tax rates	(9,921)	(8,950)
Change in valuation allowances	48,734	4,296
Nondeductible share-based compensation	1,424	645
Unrealized tax benefits	258	239
State and local taxes (net of federal)	(4,467)	60
Nondeductible interest expense	4,239	2,173
Orphan drug and R&D tax credit	0	(1,524)
Other	(326)	(1,113)
Income tax provision (benefit)	$ 26,025	$ (15,816)

Effective Income Tax Rate Reconciliation, Amount, Orphan Drug and Research And Development Tax Credit

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Effective Income Tax Rate Reconciliation, Nondeductible Expense, Interest Expense, Amount

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations.

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Amount of reported income tax expense (benefit) in excess of (less than) expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to nondeductible expense for award under share-based payment arrangement. Includes, but is not limited to, expense determined to be nondeductible upon grant or after for award under share-based payment arrangement.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to tax exempt income, equity in earnings (loss) of an unconsolidated subsidiary, minority noncontrolling interest income (loss), tax holiday, disposition of a business, disposition of an asset, repatriation of foreign earnings, repatriation of foreign earnings jobs creation act of 2004, increase (decrease) in enacted tax rate, prior year income taxes, increase (decrease) in deferred tax asset valuation allowance, and other adjustments.

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