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Share-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Compensation Expense for Share-Based Compensation Arrangements
Compensation expense included in the Company’s consolidated statements of loss for all share-based compensation arrangements was as follows for the periods ended December 31, 2022 and 2021, respectively:

Share-based Compensation Expense:20222021
Research and development $169 $758 
Selling, general and administrative 6,844 8,114 
Total share-based compensation expense$7,013 $8,872 
Schedule of Weighted-Average Assumptions
The weighted-average assumptions under the Black-Scholes option-pricing model for stock option grants as of December 31, 2022 and 2021 are as follows:   
Stock Option Assumptions: 20222021
Stock option grants:  
Expected term (years)6.096.20
Expected volatility93.41 %73.91 %
Risk-free interest rate2.73 %1.10 %
Expected dividend yield— — 
Summary of Stock Option Activity
A summary of the combined stock option activity and other data for the Company’s stock option plans for the year ended December 31, 2022 is as follows:   
 Stock Option Activity and Other Data: Number of Stock
Options
Weighted Average
Exercise Price per Share
Weighted Average
Remaining
Contractual Life
Aggregate
Intrinsic Value
Stock options outstanding, January 1, 2022
8,403 $7.39   
Granted3,268 5.29   
Exercised(450)5.46   
Forfeited(1,496)7.24   
Expired(421)9.65 
Stock options outstanding, December 31, 2022
9,304 $6.67 7.78 years$8,710 
Stock options exercisable, December 31, 2022
4,059 $7.40 6.33 years$6,859 
Summary of Restricted Share Awards and Performance Share Unit Awards
A summary of the Company’s restricted share awards as of December 31, 2022, and changes during the year then ended, is reflected in the table below. 

Restricted Share Activity and Other Data: Number of Restricted Share AwardsWeighted Average Grant Date
Fair Value
Non-vested restricted share awards outstanding, January 1, 2022
274 $7.14 
Granted— — 
Vested(144)6.37 
Forfeited(74)8.04 
Non-vested restricted share awards outstanding, December 31, 2022
56 $7.95 
A summary of the Company’s performance share units awards as of December 31, 2022, and changes during the year then ended, is reflected in the table below.

Performance Unit Share Activity and Other DataNumber of Performance Share AwardsWeighted Average Grant Date
Fair Value
Non-vested performance share awards outstanding, January 1, 2022
535 $7.71 
Granted— — 
Vested— — 
Forfeited(535)7.71 
Non-vested performance share awards outstanding, December 31, 2022
— $—