CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 60,715	$ 50,708
Marketable securities	45,760	106,513
Research and development tax credit receivable	2,077	2,443
Prepaid expenses and other current assets	4,670	32,826
Total current assets	113,222	192,490
Property and equipment, net	896	285
Operating lease right-of-use assets	1,947	2,652
Goodwill	16,836	16,836
Research and development tax credit receivable	1,137	1,225
Other non-current assets	11,720	33,777
Total assets	145,758	247,265
Current liabilities:
Current portion of long-term debt	26,299	0
Current portion of operating lease liability	1,011	900
Accounts payable	2,479	7,679
Accrued expenses	7,965	7,151
Other current liabilities	3,757	5,270
Total current liabilities	41,511	21,000
Long-term debt	109,934	142,397
Long-term operating lease liability	1,026	1,707
Other non-current liabilities	5,727	3,917
Total liabilities	158,198	169,021
Shareholders’ (deficit) equity:
Preferred shares, nominal value of $0.01 per share; 50,000 shares authorized; 488 issued and outstanding at September 30, 2022 and 488 issued and outstanding at December 31, 2021	5	5
Ordinary shares, nominal value of $0.01 per share; 500,000 shares authorized; 60,885 issued and outstanding at September 30, 2022 and 58,620 issued and outstanding at December 31, 2021	608	586
Additional paid-in capital	572,626	549,349
Accumulated deficit	(557,770)	(447,756)
Accumulated other comprehensive loss	(27,909)	(23,940)
Total shareholders’ (deficit) equity	(12,440)	78,244
Total liabilities and shareholders’ (deficit) equity	$ 145,758	$ 247,265