CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 67,142	$ 71,722
Marketable securities	135,701	149,680
Research and development tax credit receivable	2,551	3,326
Prepaid expenses and other current assets	25,308	38,726
Total current assets	230,702	263,454
Property and equipment, net	321	359
Operating lease right-of-use assets	2,249	2,604
Goodwill	16,836	16,836
Research and development tax credit receivable	983	3,445
Other non-current assets	31,500	24,939
Total assets	282,591	311,637
Current liabilities:
Current portion of operating lease liability	494	474
Accounts payable	5,116	2,934
Accrued expenses	7,524	6,501
Other current liabilities	3,146	5,200
Total current liabilities	16,280	15,109
Long-term debt	141,774	128,210
Long-term operating lease liability	1,589	1,840
Other non-current liabilities	4,068	4,212
Total liabilities	163,711	149,371
Shareholders’ equity:
Preferred shares, nominal value of $0.01 per share; 50,000 shares authorized; 488 issued and outstanding at June 30, 2021 and 488 issued and outstanding at December 31, 2020, respectively	5	5
Ordinary shares, nominal value of $0.01 per share; 500,000 shares authorized; 58,488 issued and outstanding at June 30, 2021 and 58,396 issued and outstanding at December 31, 2020	584	583
Additional paid-in capital	544,094	566,916
Accumulated deficit	(403,453)	(384,187)
Accumulated other comprehensive loss	(22,350)	(21,051)
Total shareholders’ equity	118,880	162,266
Total liabilities and shareholders’ equity	$ 282,591	$ 311,637