CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 59,172	$ 71,722
Marketable securities	145,803	149,680
Research and development tax credit receivable	3,108	3,326
Prepaid expenses and other current assets	34,231	38,726
Total current assets	242,314	263,454
Property and equipment, net	344	359
Operating lease right-of-use assets	2,427	2,604
Goodwill	16,836	16,836
Research and development tax credit receivable	3,303	3,445
Other non-current assets	27,717	24,939
Total assets	292,941	311,637
Current liabilities:
Current portion of operating lease liability	484	474
Accounts payable	2,824	2,934
Accrued expenses	4,297	6,501
Other current liabilities	1,515	5,200
Total current liabilities	9,120	15,109
Long-term debt	141,461	128,210
Long-term operating lease liability	1,717	1,840
Other non-current liabilities	4,139	4,212
Total liabilities	156,437	149,371
Shareholders’ equity:
Preferred shares, nominal value of $0.01 per share; 50,000 shares authorized; 488 issued and outstanding at March 31, 2021 and 488 issued and outstanding at December 31, 2020, respectively	5	5
Ordinary shares, nominal value of $0.01 per share; 500,000 shares authorized; 58,488 issued and outstanding at March 31, 2021 and 58,396 issued and outstanding at December 31, 2020	584	583
Additional paid-in capital	542,093	566,916
Accumulated deficit	(383,872)	(384,187)
Accumulated other comprehensive loss	(22,306)	(21,051)
Total shareholders’ equity	136,504	162,266
Total liabilities and shareholders’ equity	$ 292,941	$ 311,637