Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Current assets:
Cash and cash equivalents	$ 71,722	$ 9,774
Marketable securities	149,680	54,384
Accounts receivable	0	8,281
Inventories, net	0	3,570
Research and development tax credit receivable	3,326	2,107
Prepaid expenses and other current assets	38,726	4,264
Total current assets	263,454	82,380
Property and equipment, net	359	544
Operating lease right-of-use assets	2,604	3,612
Goodwill	16,836	18,491
Intangible assets, net	0	813
Research and development tax credit receivable	3,445	6,322
Other non-current assets	24,939	39,274
Total assets	311,637	151,436
Current liabilities:
Current portion of long-term contingent consideration payable	0	5,554
Current portion of operating lease liability	474	645
Accounts payable	2,934	6,100
Accrued expenses	6,501	19,810
Other current liabilities	5,200	3,875
Total current liabilities	15,109	35,984
Long-term debt	128,210	121,686
Long-term contingent consideration payable, less current portion	0	11,773
Long-term operating lease liability	1,840	2,319
Other non-current liabilities	4,212	8,873
Total liabilities	149,371	180,635
Shareholders’ equity (deficit):
Preferred shares, nominal value of $0.01 per share; 50,000 shares authorized; 488 issued and outstanding at December 31, 2020 and 0 issued and outstanding at December 31, 2019	5	0
Ordinary shares, nominal value of $0.01 per share; 500,000 shares authorized; 58,396 issued and outstanding at December 31, 2020, and 42,927 issued and 37,520 outstanding at December 31, 2019	583	429
Treasury shares, at cost, 0 and 5,407 shares held at December 31, 2020 and December 31, 2019, respectively	0	(49,998)
Additional paid-in capital	566,916	434,391
Accumulated deficit	(384,187)	(391,215)
Accumulated other comprehensive loss	(21,051)	(22,806)
Total shareholders’ equity (deficit)	162,266	(29,199)
Total liabilities and shareholders’ equity (deficit)	$ 311,637	$ 151,436