Company Operations by Product, Customer and Geographic Area - Revenue by Product (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2020 USD ($) segment	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)
Segment Reporting [Abstract]
Number of segments | segment	1
Segment Reporting Information [Line Items]
Total revenues	$ 22,334	$ 59,215	$ 103,269
Bloxiverz
Segment Reporting Information [Line Items]
Total revenues	2,201	7,479	20,850
Vazculep
Segment Reporting Information [Line Items]
Total revenues	10,429	33,152	42,916
Akovaz
Segment Reporting Information [Line Items]
Total revenues	9,545	18,642	33,759
Other
Segment Reporting Information [Line Items]
Total revenues	159	(58)	3,898
Product sales
Segment Reporting Information [Line Items]
Total revenues	22,334	59,215	101,423
License revenue
Segment Reporting Information [Line Items]
Total revenues	$ 0	$ 0	$ 1,846