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Property and Equipment, net
 12 Months Ended
Dec. 31, 2019
Property, Plant and Equipment [Abstract]  
Property and Equipment, net
Property and Equipment, net
The principal categories of property and equipment, net at December 31, 2019 and 2018, respectively, are as follows: 
Property and Equipment, net:
 
2019
 
2018
 
 
 
 
 
Laboratory equipment
 
$
—

 
$
8,864

Software, office and computer equipment
 
1,258

 
2,487

Furniture, fixtures and fittings
 
300

 
3,715

Less - accumulated depreciation
 
(1,014
)
 
(13,155
)
Total
 
$
544

 
$
1,911

 
The decrease in the principal categories of property and equipment, net during the year ended December 31, 2019, is a result of the restructuring efforts discussed in Note 18: Restructuring Costs.

Depreciation expense for the years ended December 31, 2019, 2018 and 2017 was $459, $811 and $1,224, respectively.