UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Cash flows from operating activities:
Net loss	$ (30,487)	$ (31,445)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	1,690	5,625
Loss on disposal of property and equipment	478	0
Amortization of premiums on marketable securities	(275)	2,889
Remeasurement of related party acquisition-related contingent consideration	2,384	(17,036)
Remeasurement of related party financing-related contingent consideration	496	(1,432)
Amortization of debt discount and debt issuance costs	4,424	3,402
Change in deferred tax and income tax deferred charge	1,333	(4,675)
Stock-based compensation expense	177	7,190
Loss on deconsolidation of subsidiary	1,750	0
Other adjustments	(392)	117
Net changes in assets and liabilities
Accounts receivable	2,026	5,059
Inventories	2,465	(548)
Prepaid expenses and other current assets	(1,859)	2,194
Research and development tax credit receivable	(749)	(1,350)
Accounts payable & other current liabilities	259	4,312
Accrued expenses	(2,379)	(11,660)
Earn-out payments for related party contingent consideration in excess of acquisition-date fair value	(8,640)	(16,254)
Royalty payments for related party payable in excess of original fair value	(1,374)	(2,362)
Other assets and liabilities	(1,399)	(2,216)
Net cash used in operating activities	(30,072)	(58,190)
Cash flows from investing activities:
Purchases of property and equipment	(29)	(167)
Proceeds from the disposal of property and equipment	154	0
Purchase of intangible asset	0	(20,000)
Proceeds from sales of marketable securities	57,242	308,015
Purchases of marketable securities	(23,814)	(341,036)
Net cash provided by (used in) investing activities	33,553	(53,188)
Cash flows from financing activities:
Earn-out payments for related party contingent consideration	0	(645)
Proceeds from debt issuance	0	143,750
Payments for debt issuance costs	0	(6,190)
Share repurchases	0	(27,637)
Proceeds from issuance of ordinary shares and warrants	123	3,488
Other financing activities, net	(109)	(31)
Net cash provided by financing activities	14	112,735
Effect of foreign currency exchange rate changes on cash and cash equivalents	47	(84)
Net change in cash and cash equivalents	3,542	1,273
Cash and cash equivalents at January 1,	9,325	16,564
Cash and cash equivalents at September 30,	12,867	17,837
Supplemental disclosures of cash flow information:
Interest paid	6,469	3,359
Income taxes paid	$ 140	$ 413