UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Cash flows from operating activities:
Net loss	$ (21,623)	$ (15,674)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	1,064	3,810
Loss on disposal of property and equipment	478	0
Amortization of premiums on marketable securities	17	1,693
Remeasurement of related party acquisition-related contingent consideration	1,757	(9,921)
Remeasurement of related party financing-related contingent consideration	357	(1,007)
Amortization of debt discount and debt issuance costs	2,918	2,019
Change in deferred tax and income tax deferred charge	1,900	(3,247)
Stock-based compensation expense	406	4,358
Loss on deconsolidation of subsidiary	1,750	0
Other adjustments	(1,012)	91
Net changes in assets and liabilities
Accounts receivable	579	(157)
Inventories	2,124	(242)
Prepaid expenses and other current assets	(1,829)	1,587
Research and development tax credit receivable	(593)	(1,003)
Accounts payable & other current liabilities	3,127	5,206
Accrued expenses	(3,737)	(9,831)
Earn-out payments for related party contingent consideration in excess of acquisition-date fair value	(5,790)	(11,113)
Royalty payments for related party payable in excess of original fair value	(917)	(1,618)
Other assets and liabilities	(3,629)	(2,893)
Net cash used in operating activities	(22,653)	(37,942)
Cash flows from investing activities:
Purchases of property and equipment	(29)	(99)
Proceeds from the disposal of property and equipment	154	0
Purchase of intangible asset	0	(20,000)
Proceeds from sales of marketable securities	52,202	253,525
Purchases of marketable securities	(21,991)	(312,638)
Net cash provided by (used in) investing activities	30,336	(79,212)
Cash flows from financing activities:
Earn-out payments for related party contingent consideration	0	(645)
Proceeds from debt issuance	0	143,750
Payments for debt issuance costs	0	(5,760)
Share repurchases	0	(27,637)
Proceeds from issuance of ordinary shares and warrants	92	3,446
Other financing activities, net	(37)	6
Net cash provided by financing activities	55	113,160
Effect of foreign currency exchange rate changes on cash and cash equivalents	48	(93)
Net change in cash and cash equivalents	7,786	(4,087)
Cash and cash equivalents at January 1,	9,325	16,564
Cash and cash equivalents at June 30,	17,111	12,477
Supplemental disclosures of cash flow information:
Interest paid	3,234	394
Income taxes paid	$ 140	$ 409