UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Cash flows from operating activities:
Net loss	$ (13,018)	$ (12,236)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	369	1,985
Amortization of premiums on marketable securities	9	518
Remeasurement of related party acquisition-related contingent consideration	2,134	2,968
Remeasurement of related party financing-related contingent consideration	307	395
Amortization of debt discount and debt issuance costs	1,445	657
Change in deferred tax and income tax deferred charge	(222)	(2,851)
Stock-based compensation expense	351	2,134
Loss on deconsolidation of subsidiary	1,750	0
Other adjustments	(550)	139
Net changes in assets and liabilities
Accounts receivable	(1,021)	(1,891)
Inventories	467	(466)
Prepaid expenses and other current assets	(3,228)	(2,285)
Research and development tax credit receivable	(449)	(494)
Accounts payable & other current liabilities	752	6,374
Accrued expenses	(4,750)	(5,854)
Accrued income taxes	(46)	32
Earn-out payments for related party contingent consideration in excess of acquisition-date fair value	(3,181)	(5,790)
Royalty payments for related party payable in excess of original fair value	(507)	(825)
Other assets and liabilities	(1,818)	(518)
Net cash used in operating activities	(21,206)	(18,008)
Cash flows from investing activities:
Purchases of property and equipment	(30)	(41)
Proceeds from sales of marketable securities	34,864	194,400
Purchases of marketable securities	(13,444)	(275,098)
Net cash provided by (used in) investing activities	21,390	(80,739)
Cash flows from financing activities:
Earn-out payments for related party contingent consideration	0	(402)
Proceeds from debt issuance	0	143,750
Payments for debt issuance costs	0	(5,391)
Share repurchases	0	(18,000)
Proceeds from exercise of warrants	0	2,911
Other financing activities, net	92	47
Net cash provided by financing activities	92	122,915
Effect of foreign currency exchange rate changes on cash and cash equivalents	29	179
Net change in cash and cash equivalents	305	24,347
Cash and cash equivalents at January 1,	9,325	16,564
Cash and cash equivalents at March 31,	9,630	40,911
Supplemental disclosures of cash flow information:
Interest paid	3,234	263
Income taxes paid	$ 72	$ 90