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Long-Term Related Party Payable - Activity (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Long-Term Related Party Payable      
Related party payable, beginning balance $ 98,925 $ 169,347 $ 122,693
Payments to Related Parties (22,951) (37,311) (30,838)
Operating (Gain) Expense (22,731) (31,040) 49,285
Other Income (1,899)    
Expiration of Warrants (2,167)    
Disposal (20,337)    
Related party payable, ending balance 28,840 98,925 $ 169,347
Less: Current portion (9,439) (25,007)  
Total long-term related party payable 19,401 73,918  
Financing-related:      
Long-Term Related Party Payable      
Related party payable, beginning balance 15,000    
Payments to Related Parties 0    
Operating (Gain) Expense 0    
Other Income 0    
Expiration of Warrants 0    
Disposal (15,000)    
Related party payable, ending balance 0 15,000  
Warrant | Acquisition-related contingent consideration:      
Long-Term Related Party Payable      
Related party payable, beginning balance 2,479    
Payments to Related Parties 0    
Operating (Gain) Expense (312)    
Other Income 0    
Expiration of Warrants (2,167)    
Disposal 0    
Related party payable, ending balance 0 2,479  
Earn-out payments | Acquisition-related contingent consideration:      
Long-Term Related Party Payable      
Related party payable, beginning balance 67,744    
Payments to Related Parties (19,468)    
Operating (Gain) Expense (22,661)    
Other Income 0    
Expiration of Warrants 0    
Disposal 0    
Related party payable, ending balance 25,615 67,744  
Royalty agreement - FSC | Acquisition-related contingent consideration:      
Long-Term Related Party Payable      
Related party payable, beginning balance 5,740    
Payments to Related Parties (645)    
Operating (Gain) Expense 242    
Other Income 0    
Expiration of Warrants 0    
Disposal (5,337)    
Related party payable, ending balance 0 5,740  
Royalty agreement - Deerfield | Financing-related:      
Long-Term Related Party Payable      
Related party payable, beginning balance 5,392    
Payments to Related Parties (1,922)    
Operating (Gain) Expense 0    
Other Income (1,286)    
Expiration of Warrants 0    
Disposal 0    
Related party payable, ending balance 2,184 5,392  
Royalty agreement - Broadfin | Financing-related:      
Long-Term Related Party Payable      
Related party payable, beginning balance 2,570    
Payments to Related Parties (916)    
Operating (Gain) Expense 0    
Other Income (613)    
Expiration of Warrants 0    
Disposal 0    
Related party payable, ending balance $ 1,041 $ 2,570