Goodwill and Intangible Assets - Net Book Value (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Amortizable intangible assets:
Amortizable intangible assets: Gross Value	$ 85,172,000	$ 106,072,000
Amortizable intangible assets: Accumulated Amortization	(17,456,000)	(13,783,000)
Amortizable intangible assets, Impairment	(66,087,000)
Amortizable intangible assets: Net Book Value	1,629,000	92,289,000
Unamortizable intangible assets:
Unamortizable intangible assets: Goodwill, Gross Value	18,491,000	18,491,000
Unamortizable intangible assets: Accumulated Amortization	0	0
Unamortizable intangible assets: Net Book Value	18,491,000	18,491,000
In Process Research and Development | Noctiva
Amortizable intangible assets:
Amortizable intangible assets: Gross Value	73,111,000	73,111,000
Amortizable intangible assets: Accumulated Amortization	(7,024,000)	(1,401,000)
Amortizable intangible assets, Impairment	(66,087,000)
Amortizable intangible assets: Net Book Value	0	71,710,000
In Process Research and Development | Vazculep
Amortizable intangible assets:
Amortizable intangible assets: Gross Value	12,061,000	12,061,000
Amortizable intangible assets: Accumulated Amortization	(10,432,000)	(9,616,000)
Amortizable intangible assets, Impairment	0
Amortizable intangible assets: Net Book Value	1,629,000	2,445,000
Marketing Rights
Amortizable intangible assets:
Amortizable intangible assets: Gross Value	0	16,600,000
Amortizable intangible assets: Accumulated Amortization	0	(2,132,000)
Amortizable intangible assets, Impairment	0
Amortizable intangible assets: Net Book Value	0	14,468,000
Developed Technology
Amortizable intangible assets:
Amortizable intangible assets: Gross Value	0	4,300,000
Amortizable intangible assets: Accumulated Amortization	0	(634,000)
Amortizable intangible assets, Impairment	0
Amortizable intangible assets: Net Book Value	$ 0	$ 3,666,000