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Equity Instruments and Stock Based Compensation (Tables)
12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs
Compensation expense included in the Company’s consolidated statements of (loss) income for all stock-based compensation arrangements was as follows for the periods ended December 31: 
Stock-based Compensation Expense:
 
2018
 
2017
 
2016
 
 
 
 
 
 
 
Research and development
 
$
880

 
$
672

 
$
3,523

Selling, general and administrative
 
6,972

 
7,400

 
11,156

Total stock-based compensation expense
 
$
7,852

 
$
8,072

 
$
14,679

Schedule of Share Based Payment Award Stock Options and Warrant Grants Valuation Assumptions
The weighted-average assumptions under the Black-Scholes option-pricing model for stock option and warrant grants as of December 31, 2018, 2017 and 2016, are as follows:   
Stock Option and Warrant Assumptions:
 
2018
 
2017
 
2016
 
 
 
 
 
 
 
Stock option grants:
 
 

 
 

 
 

Expected term (years)
 
6.25

 
6.25

 
6.25

Expected volatility
 
56.59
%
 
58.82
%
 
58.39
%
Risk-free interest rate
 
2.68
%
 
2.20
%
 
2.04
%
Expected dividend yield
 

 

 

 
 
 
 
 
 
 
Warrant grants:
 
 

 
 

 
 

Expected term (years)
 

 
0

 
2.50

Expected volatility
 
%
 
%
 
60.57
%
Risk-free interest rate
 
%
 
%
 
0.82
%
Expected dividend yield
 

 

 

Schedule of Share-based Compensation, Stock Options, Activity
A summary of the combined stock option activity and other data for the Company’s stock option plans for the year ended December 31, 2018 is as follows:   
 Stock Option Activity and Other Data:
 
Number of Stock
Options
 
Weighted Average
Exercise Price per Share
 
Weighted Average
Remaining
Contractual Life
 
Aggregate
Intrinsic Value
 
 
 
 
 
 
 
 
 
Stock options outstanding, January 1, 2018
 
5,041

 
$
11.34

 
 
 
 

Granted
 
138

 
6.67

 
 
 
 

Exercised
 
(82
)
 
6.52

 
 
 
 

Forfeited
 
(428
)
 
10.04

 
 
 
 

Expired
 
(68
)
 
12.41

 
 
 
 
Stock options outstanding, December 31, 2018
 
4,601

 
$
11.39

 
7.25 years
 
$

Stock options exercisable, December 31, 2018
 
3,005

 
$
11.99

 
6.66 years
 
$

Schedule of Stockholders' Equity Note, Warrants or Rights
A summary of the combined warrant activity and other data for the year ended December 31, 2018 is as follows:   
 Warrant Activity and Other Data:
 
Number of
Warrants
 
Weighted Average Exercise Price per Share
 
Weighted Average Remaining
Contractual Life
 
Aggregate Intrinsic
Value
 
 
 
 
 
 
 
 
 
Warrants outstanding, January 1, 2018
 
894

 
$
16.77

 
 
 
 

Granted
 

 

 
 
 
 

Exercised
 

 

 
 
 
 

Forfeited
 

 

 
 
 
 

Expired
 
(298
)
 
14.87

 
 
 
 
Warrants outstanding, December 31, 2018
 
596

 
$
17.72

 
1.03 years
 
$

Warrants exercisable, December 31, 2018
 
596

 
$
17.72

 
1.03 years
 
$

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award
A summary of the Company’s restricted share awards as of December 31, 2018, and changes during the year then ended, is reflected in the table below. 
Restricted Share Activity and Other Data:
 
Number of Restricted Share Awards
 
Weighted Average Grant Date
Fair Value
 
 
 
 
 
Non-vested restricted share awards outstanding, January 1, 2018
 
819

 
$
11.51

Granted
 
279

 
5.87

Vested
 
(548
)
 
12.78

Forfeited
 
(59
)
 
8.95

Non-vested restricted share awards outstanding, December 31, 2018
 
491

 
$
7.20