Company Operations by Product, Customer and Geographic Area - Revenue by Product (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Segment Reporting Information [Line Items]
Total revenues	$ 103,269	$ 173,245	$ 150,246
Bloxiverz
Segment Reporting Information [Line Items]
Total revenues	20,850	45,596	82,896
Vazculep
Segment Reporting Information [Line Items]
Total revenues	42,916	38,187	39,796
Akovaz
Segment Reporting Information [Line Items]
Total revenues	33,759	80,617	16,831
Noctiva
Segment Reporting Information [Line Items]
Total revenues	1,204	0	0
Other
Segment Reporting Information [Line Items]
Total revenues	2,694	8,441	7,699
Product sales
Segment Reporting Information [Line Items]
Total revenues	101,423	172,841	147,222
License revenue
Segment Reporting Information [Line Items]
Total revenues	$ 1,846	$ 404	$ 3,024