UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017
Cash flows from operating activities:
Net (loss) income	$ (31,445)	$ 76,516
Adjustments to reconcile net (loss) income to net cash provided by operating activities:
Depreciation and amortization	5,625	2,664
Amortization of premiums on marketable securities	2,889	653
Remeasurement of related party acquisition-related contingent consideration	(17,036)	(30,107)
Remeasurement of related party financing-related contingent consideration	(1,432)	(2,988)
Amortization of debt discount and debt issuance costs	3,402	0
Change in deferred tax and income tax deferred charge	(4,675)	322
Stock-based compensation expense	7,190	6,019
Other adjustments	117	(1,076)
Net changes in assets and liabilities
Accounts receivable	5,059	(6,240)
Inventories	(548)	(2,612)
Prepaid expenses and other current assets	2,194	1,924
Research and development tax credit receivable	(1,350)	(1,576)
Accounts payable & other current liabilities	4,312	804
Accrued expenses	(11,660)	9,324
Accrued income taxes	(228)	5,826
Earn-out payments for related party contingent consideration in excess of acquisition-date fair value	(16,254)	(24,729)
Royalty payments for related party payable in excess of original fair value	(2,362)	(3,446)
Other assets and liabilities	(1,988)	(800)
Net cash (used in) provided by operating activities	(58,190)	30,478
Cash flows from investing activities:
Purchases of property and equipment	(167)	(533)
Purchase of intangible asset	(20,000)	(52,139)
Proceeds from sales of marketable securities	308,015	153,398
Purchases of marketable securities	(341,036)	(115,893)
Net cash used in investing activities	(53,188)	(15,167)
Cash flows from financing activities:
Earn-out payments for related party contingent consideration	(645)	(961)
Proceeds from debt issuance	143,750	0
Payments for debt issuance costs	(6,190)	0
Share repurchases	(27,637)	(16,707)
Proceeds from the issuance of ordinary shares and warrants	3,488	376
Other financing activities, net	(31)	0
Net cash provided by (used in) financing activities	112,735	(17,292)
Effect of foreign currency exchange rate changes on cash and cash equivalents	(84)	215
Net change in cash and cash equivalents	1,273	(1,766)
Cash and cash equivalents at January 1,	16,564	39,215
Cash and cash equivalents at September 30,	17,837	37,449
Supplemental disclosures of cash flow information:
Interest paid	3,359	525
Income taxes paid	$ 413	$ 9,605