Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Income Statement [Abstract]
Collaboration revenue	$ 206,165	$ 175,657	$ 388,662	$ 304,845
Operating expenses:
Research and development expenses	73,375	47,294	150,962	91,970
Selling, general and administrative expenses	758,431	74,708	855,258	158,647
Total operating expenses	831,806	122,002	1,006,220	250,617
Income (loss) from operations	(625,641)	53,655	(617,558)	54,228
Other income (expense), net:
Loss on extinguishment of Convertible Notes		(7,868)		(7,871)
Interest expense	(475)	(5,309)	(1,155)	(10,917)
Other, net	(23)	(52)	(232)	88
Total other income (expense), net	(498)	(13,229)	(1,387)	(18,700)
Income (loss) before income tax (expense) benefit	(626,139)	40,426	(618,945)	35,528
Income tax (expense) benefit	222,217	(14,600)	219,839	(12,820)
Net income (loss)	$ (403,922)	$ 25,826	$ (399,106)	$ 22,708
Basic net income (loss) per common share	$ (2.45)	$ 0.16	$ (2.42)	$ 0.14
Diluted net income (loss) per common share	$ (2.45)	$ 0.15	$ (2.42)	$ 0.14
Weighted average common shares used in the calculation of basic net income (loss) per common share	164,926	158,505	164,586	157,576
Weighted average common shares used in the calculation of diluted net income (loss) per common share	164,926	168,690	164,586	162,995