Income Taxes	6 Months Ended
Jun. 30, 2016
Income Tax Disclosure [Abstract]
Income Taxes	NOTE 14. INCOME TAXES The Company calculates its quarterly income tax provision in accordance with the guidance provided by ASC 740-270, “Interim Income Tax Accounting,” whereby the Company forecasts its estimated annual effective tax rate and then applies that rate to its year-to-date pre-tax book income (loss). Income tax benefit for the three and six months ended June 30, 2016 was $222.2 million and $219.8 million, respectively. The benefit for income taxes was higher than the tax computed at the U.S. federal statutory rate due primarily to the Federal research and development credit and tax benefit from stock-based compensation, partially offset by state income taxes and non-deductible officers’ compensation. The benefit for income taxes for the three and six months ended June 30, 2016 included discrete tax benefits of $236.4 million and $2.2 million related to non-recurring charges for contingent consideration and advisory mergers and acquisitions fees, respectively. In addition, the Company recorded a discrete tax expense of $1.6 million related to a non-recurring IPR&D asset impairment adjustment. Income tax expense for the three and six months ended June 30, 2015 was $14.6 million and $12.8 million, respectively. A discrete tax benefit of $2.8 million related to the loss on extinguishment of the Convertible Notes was included in the provision for income taxes for the three and six months ended June 30, 2015. The effective tax rate was 35.5% for both the three and six months ended June 30, 2016. The effective tax rate was 36.1% for both the three and six months ended June 30, 2015. The decrease in the effective tax rate for the three and six months ended June 30, 2016 as compared to the prior year periods was due to the Federal research and development tax credit which was permanently reinstated in the fourth quarter of 2015 and greater tax benefits from stock-based compensation in the second quarter of 2016. For the six months ended June 30, 2016, the Company reduced its current Federal and state taxes payable by $13.4 million related to excess tax benefits from stock-based compensation, increasing additional paid-in capital. The Company records a valuation allowance to reduce deferred tax assets to reflect the net amount that is more likely than not to be realized. Based upon the weight of available evidence at December 31, 2014, the Company determined that it was more likely than not that a portion of its deferred tax assets would be realizable and consequently released the valuation allowance against Federal and certain state net deferred tax assets during the fourth quarter of 2014. The decision to reverse a portion of the valuation allowance was made after management considered all available evidence, both positive and negative, including but not limited to the historical operating results, income or loss in recent periods, cumulative income in recent years, forecasted earnings, forecasted future taxable income, and significant risk and uncertainty related to forecasts. The release of the valuation allowance resulted in the recognition of certain deferred net tax assets and a decrease to income tax expense. The future effective tax rate is subject to volatility and may be materially impacted by various internal and external factors. These factors may include, but are not limited to, the amount of income tax benefits and charges from: interpretations of existing tax laws; changes in tax laws and rates; future levels of research and development expenditures; changes in the mix of earnings in countries with differing statutory tax rates in which the Company may conduct business; changes in the valuation of deferred tax assets and liabilities; state income taxes; the tax impact of stock-based compensation; accounting for uncertain tax positions; closure of statute of limitations or settlement of tax audits; changes in estimates of prior years’ items; tax costs for acquisition-related items; changes in accounting standards; non-deductible officers’ compensation; limitations on the utilization of net operating losses and tax credits due to changes in ownership; and overall levels of income before taxes.

NOTE 14. INCOME TAXES

The Company calculates its quarterly income tax provision in accordance with the guidance provided by ASC 740-270, “Interim Income Tax Accounting,” whereby the Company forecasts its estimated annual effective tax rate and then applies that rate to its year-to-date pre-tax book income (loss). Income tax benefit for the three and six months ended June 30, 2016 was $222.2 million and $219.8 million, respectively. The benefit for income taxes was higher than the tax computed at the U.S. federal statutory rate due primarily to the Federal research and development credit and tax benefit from stock-based compensation, partially offset by state income taxes and non-deductible officers’ compensation. The benefit for income taxes for the three and six months ended June 30, 2016 included discrete tax benefits of $236.4 million and $2.2 million related to non-recurring charges for contingent consideration and advisory mergers and acquisitions fees, respectively. In addition, the Company recorded a discrete tax expense of $1.6 million related to a non-recurring IPR&D asset impairment adjustment. Income tax expense for the three and six months ended June 30, 2015 was $14.6 million and $12.8 million, respectively. A discrete tax benefit of $2.8 million related to the loss on extinguishment of the Convertible Notes was included in the provision for income taxes for the three and six months ended June 30, 2015.

The effective tax rate was 35.5% for both the three and six months ended June 30, 2016. The effective tax rate was 36.1% for both the three and six months ended June 30, 2015. The decrease in the effective tax rate for the three and six months ended June 30, 2016 as compared to the prior year periods was due to the Federal research and development tax credit which was permanently reinstated in the fourth quarter of 2015 and greater tax benefits from stock-based compensation in the second quarter of 2016.

For the six months ended June 30, 2016, the Company reduced its current Federal and state taxes payable by $13.4 million related to excess tax benefits from stock-based compensation, increasing additional paid-in capital.

The Company records a valuation allowance to reduce deferred tax assets to reflect the net amount that is more likely than not to be realized. Based upon the weight of available evidence at December 31, 2014, the Company determined that it was more likely than not that a portion of its deferred tax assets would be realizable and consequently released the valuation allowance against Federal and certain state net deferred tax assets during the fourth quarter of 2014. The decision to reverse a portion of the valuation allowance was made after management considered all available evidence, both positive and negative, including but not limited to the historical operating results, income or loss in recent periods, cumulative income in recent years, forecasted earnings, forecasted future taxable income, and significant risk and uncertainty related to forecasts. The release of the valuation allowance resulted in the recognition of certain deferred net tax assets and a decrease to income tax expense.

The future effective tax rate is subject to volatility and may be materially impacted by various internal and external factors. These factors may include, but are not limited to, the amount of income tax benefits and charges from: interpretations of existing tax laws; changes in tax laws and rates; future levels of research and development expenditures; changes in the mix of earnings in countries with differing statutory tax rates in which the Company may conduct business; changes in the valuation of deferred tax assets and liabilities; state income taxes; the tax impact of stock-based compensation; accounting for uncertain tax positions; closure of statute of limitations or settlement of tax audits; changes in estimates of prior years’ items; tax costs for acquisition-related items; changes in accounting standards; non-deductible officers’ compensation; limitations on the utilization of net operating losses and tax credits due to changes in ownership; and overall levels of income before taxes.