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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Cash flows from operating activities:      
Net income (loss) $ 276,452us-gaap_NetIncomeLoss $ (42,613)us-gaap_NetIncomeLoss $ (41,257)us-gaap_NetIncomeLoss
Adjustments for non-cash operating items:      
Release of valuation allowance for deferred income taxes (33,403)mdvn_ReleaseOfValuationAllowanceForDeferredIncomeTaxes    
Excess tax benefits from stock-based compensation (16,965)us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities    
Changes in deferred income taxes (3,827)us-gaap_IncreaseDecreaseInDeferredIncomeTaxes    
Amortization of deferred revenue (14,109)us-gaap_RecognitionOfDeferredRevenue (25,396)us-gaap_RecognitionOfDeferredRevenue (100,944)us-gaap_RecognitionOfDeferredRevenue
Stock-based compensation 45,134us-gaap_ShareBasedCompensation 37,078us-gaap_ShareBasedCompensation 23,678us-gaap_ShareBasedCompensation
Amortization of debt discount and debt issuance costs 14,898us-gaap_AmortizationOfFinancingCostsAndDiscounts 13,456us-gaap_AmortizationOfFinancingCostsAndDiscounts 9,663us-gaap_AmortizationOfFinancingCostsAndDiscounts
Depreciation on property and equipment 5,239us-gaap_DepreciationDepletionAndAmortization 3,449us-gaap_DepreciationDepletionAndAmortization 1,614us-gaap_DepreciationDepletionAndAmortization
Asset impairment and other charges 1,124us-gaap_AssetImpairmentCharges 158us-gaap_AssetImpairmentCharges 80us-gaap_AssetImpairmentCharges
Accretion of discount on securities   (168)us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments (166)us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments
Changes in operating assets and liabilities:      
Receivable from collaboration partners (77,527)mdvn_IncreaseDecreaseInReceivableFromCollaborationPartners (71,752)mdvn_IncreaseDecreaseInReceivableFromCollaborationPartners (22,913)mdvn_IncreaseDecreaseInReceivableFromCollaborationPartners
Prepaid expenses and other current assets 301us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (3,953)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (1,114)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Other non-current assets (401)us-gaap_IncreaseDecreaseInOtherNoncurrentAssets (7,353)us-gaap_IncreaseDecreaseInOtherNoncurrentAssets (581)us-gaap_IncreaseDecreaseInOtherNoncurrentAssets
Accounts payable, accrued expenses and other current liabilities 43,935us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities 27,889us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities 19,312us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities
Other non-current liabilities (252)us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities 996us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities 8,210us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities
Interest payable     1,698us-gaap_IncreaseDecreaseInInterestPayableNet
Net cash provided by (used) in operating activities 240,599us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (68,209)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (102,720)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities:      
Purchases of property and equipment (10,544)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (7,535)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (13,972)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Payments to CureTech, Ltd. under License Agreement (5,000)us-gaap_PaymentsToAcquireBusinessesGross    
Change in restricted cash (1,866)us-gaap_IncreaseDecreaseInRestrictedCash (713)us-gaap_IncreaseDecreaseInRestrictedCash (3,197)us-gaap_IncreaseDecreaseInRestrictedCash
Reduction of build to suit obligation (135)mdvn_LeasePaymentsAppliedToReduceBuildToSuitObligation    
Purchases of short-term investments   (144,926)us-gaap_PaymentsToAcquireShortTermInvestments (424,757)us-gaap_PaymentsToAcquireShortTermInvestments
Maturities of short-term investments   370,000us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments 275,000us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments
Net cash (used in) provided by investing activities (17,545)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations 216,826us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (166,926)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities:      
Proceeds from issuance of common stock under equity incentive and stock purchase plans 33,882us-gaap_ProceedsFromStockPlans 8,870us-gaap_ProceedsFromStockPlans 22,046us-gaap_ProceedsFromStockPlans
Excess tax benefits from stock-based compensation 16,965us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities    
Repayment of Convertible Notes (12)us-gaap_RepaymentsOfConvertibleDebt    
Proceeds from issuance of Convertible Notes, net     250,987us-gaap_ProceedsFromConvertibleDebt
Financing transaction costs     (614)us-gaap_PaymentsOfFinancingCosts
Tax withholdings related to net share settlement of performance share awards     (1,608)us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation
Net cash provided by financing activities 50,835us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 8,870us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 270,811us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Net increase in cash and cash equivalents 273,889us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 157,487us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 1,165us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease
Cash and cash equivalents at beginning of year 228,788us-gaap_CashAndCashEquivalentsAtCarryingValue 71,301us-gaap_CashAndCashEquivalentsAtCarryingValue 70,136us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents at end of year 502,677us-gaap_CashAndCashEquivalentsAtCarryingValue 228,788us-gaap_CashAndCashEquivalentsAtCarryingValue 71,301us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosures of cash flow information:      
Interest 6,792us-gaap_InterestPaidNet 6,792us-gaap_InterestPaidNet 3,623us-gaap_InterestPaidNet
Income taxes, net of refunds 1,525us-gaap_IncomeTaxesPaidNet (127)us-gaap_IncomeTaxesPaidNet 23us-gaap_IncomeTaxesPaidNet
Non-cash investing and financing activities:      
Amounts capitalized under build-to-suit lease transactions 18,085us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1    
Interest capitalized during construction period for build-to-suit lease transactions 1,459mdvn_InterestCapitalizedForBuildToSuitTransactions    
Property and equipment expenditures incurred but not yet paid 242us-gaap_CapitalExpendituresIncurredButNotYetPaid 99us-gaap_CapitalExpendituresIncurredButNotYetPaid 254us-gaap_CapitalExpendituresIncurredButNotYetPaid
Stock appreciation rights-reclassification from current liabilities to stockholders' equity     $ 110us-gaap_StockholdersEquityOther