Exhibit 12.1

Medivation, Inc.

Computation of Ratio of Earnings to Fixed Charges

(unaudited - in thousands)

	Years Ended December 31,
	2011			2010			2009			2008			2007
Earnings
Net loss before income taxes	$	(43,172	)	$	(32,465	)	$	(46,481	)	$	(62,470	)	$	(31,741	)
Fixed charges		933			733			933			200			133
Earnings, as defined	$	(42,239	)	$	(31,732	)	$	(45,548	)	$	(62,270	)	$	(31,608	)
Fixed Charges
Interest component of rentals (1)	$	933		$	733		$	933		$	200		$	133
Total	$	933		$	733		$	933		$	200		$	133
Deficiency in earnings to cover fixed charges	$	43,172		$	32,465		$	46,481		$	62,470		$	31,741
Ratio of earnings to fixed charges		*			*			*			*			*

(1) Represents the estimated portion of operating lease rental expense that is considered by us to be a reasonable representation of interest.

* Because of the deficiency in earnings to cover fixed charges, the ratio information is not applicable.