Income Taxes (Tables)

12 Months Ended

Dec. 31, 2011

Income Taxes [Abstract]

Schedule Of Income Tax Expense (Benefit)

	Years Ended December 31,
	2011			2010			2009
Current:
Federal	$	(4,309	)	$	5,012		$	441
State		(22	)		(3,440	)		7,831
Total current		(4,331	)		1,572			8,272
Deferred:
Federal		—			—			—
State		—			—			—
Total deferred		—			—			—
Total income tax (benefit) expense	$	(4,331	)	$	1,572		$	8,272

Schedule Of Reconciliation Of The Statutory Federal Income Rate

	Years Ended December 31,
	2011			2010			2009
Federal tax provision at statutory rate		35.00	%		35.00	%		35.00	%
State taxes (net of Federal benefit)		2.27	%		(4.17	%)		6.91	%
Change in reserve		(0.94	%)		(1.84	%)		—
Orphan drug credit		(0.70	%)		(1.06	%)		—
Stock-based compensation		0.06	%		(2.03	%)		(1.26	%)
Change in valuation allowance		(29.94	%)		(39.65	%)		(66.60	%)
Research and development credits		7.05	%		9.72	%		6.54	%
Net proceeds from stockholder securities law settlement		(2.43	%)		—			—
Other		(0.33	%)		(0.81	%)		1.52	%
Benefit (provision) for taxes		10.04	%		(4.84	%)		(17.89	%)

Schedule Of Company's Deferred Tax Assets

	December 31,
	2011			2010
Deferred tax assets:
Deferred revenue	$	54,116		$	76,638
Net operating loss carry forward		30,767			4,786
Stock-based compensation		9,872			8,243
Research and development credits		11,280			3,280
Depreciation, amortization and other		133			120
Accruals and reserves		552			729
Total deferred tax assets		106,720			93,796
Less: valuation allowance		(106,720	)		(93,796	)
Net deferred tax assets	$	—		$	—

Schedule Of Gross Unrecognized Tax Positions

	December 31,
	2011			2010		2009
Balance as of beginning of year	$	4,128		$	889	$	358
Additions based on tax positions related to the current year		500			393		429
Additions based on tax position related to prior year		109			2,846		102
Decreases based on tax positions related to prior year		(801	)		—		—
Balance as of end of year	$	3,936		$	4,128	$	889