Exhibit 16.1

LOS ANGELES 10960 Wilshire Blvd Suite 1100 Los Angeles, CA 90024 Telephone: 310.477.3924 Fax: 310.478.6070 877-SLGG-LLP (877) 754-4557   SERVICES Audit & Accounting Business Management Business Valuation Litigation Support Enterprise Risk Management Forensic Accounting SEC Small Business Tax Consultation   INDUSTRIES Construction Entertainment & Media Manufacturing Distribution & Retail Nonprofit Sector Professional Services Real Estate Technology & Life Sciences Securities and Exchange Commission (SEC) 450 Fifth Street NW Washington, D.C. 20549   Commissioners:   We have read Medivation, Inc.’s statements included under Item 4.01 of its Form 8-K filed on March 23, 2007, and we agree with such statements concerning our firm.   SINGER LEWAK GREENBAUM & GOLDSTEIN LLP

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