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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-10-046691.txt : 20100914
<SEC-HEADER>0001181431-10-046691.hdr.sgml : 20100914
<ACCEPTANCE-DATETIME>20100914204439
ACCESSION NUMBER:		0001181431-10-046691
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100909
FILED AS OF DATE:		20100914
DATE AS OF CHANGE:		20100914

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIVATION, INC.
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105
		BUSINESS PHONE:		415-543-3470

	MAIL ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORION ACQUISITION CORP II
		DATE OF NAME CHANGE:	19960408

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			QVT Associates GP LLC
		CENTRAL INDEX KEY:			0001290166
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32836
		FILM NUMBER:		101072738

	BUSINESS ADDRESS:	
		STREET 1:		1177 AVENUE OF THE AMERICAS
		STREET 2:		9TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		212-705-8800

	MAIL ADDRESS:	
		STREET 1:		1177 AVENUE OF THE AMERICAS
		STREET 2:		9TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd286249.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-09-09</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>MEDIVATION, INC.</issuerName>
        <issuerTradingSymbol>MDVN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001290166</rptOwnerCik>
            <rptOwnerName>QVT Associates GP LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1177 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>9TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $0.01 par value</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3510116</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Through each of the funds listed under footnotes 1 &amp; 2</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">QVT Fund LP directly beneficially owns 1,252,017 shares of Common Stock, Quintessence Fund L.P. directly beneficially owns 393,333 shares of Common Stock, QVT Overseas II L.P. directly beneficially owns 491,526 shares of Common Stock, QVT Associates II LP directly beneficially owns 632,589 shares of Common Stock and QVT International II L.P. directly beneficially owns 740,651 shares of Common Stock (Continued in footnote 2).</footnote>
        <footnote id="F2">QVT Associates GP LLC, as the General Partner of QVT Fund LP, Quintessence Fund L.P., QVT Overseas II L.P., QVT Associates II LP and QVT International II L.P., may be deemed to beneficially own the aggregate number of shares of Common Stock owned by QVT Fund LP, Quintessence Fund L.P., QVT Overseas II L.P., QVT Associates II LP and QVT International II L.P.,  and accordingly, QVT Associates GP LLC may be deemed to be the indirect beneficial owner of an aggregate amount of 3,510,116 shares of Common Stock.  The reporting person disclaims beneficial ownership of the reported securities except to the extent of its pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Tracy Fu, Managing Member</signatureName>
        <signatureDate>2010-09-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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