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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 S5ED0UsLwl26iMThQcVlMMOyHKGeOuTBVS6kF7nc9Y7aiHbtVGX7nKJeUW0yZPFy
 kBdFDb4Xu41x8CT6ePWT0w==

<SEC-DOCUMENT>0001181431-10-027739.txt : 20100518
<SEC-HEADER>0001181431-10-027739.hdr.sgml : 20100518
<ACCEPTANCE-DATETIME>20100518190444
ACCESSION NUMBER:		0001181431-10-027739
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100517
FILED AS OF DATE:		20100518
DATE AS OF CHANGE:		20100518

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PALEKAR ROHAN
		CENTRAL INDEX KEY:			0001423327

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32836
		FILM NUMBER:		10843874

	MAIL ADDRESS:	
		STREET 1:		201 SPEAR STREET, THIRD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIVATION, INC.
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105
		BUSINESS PHONE:		415-543-3470

	MAIL ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORION ACQUISITION CORP II
		DATE OF NAME CHANGE:	19960408
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd276079.xml
<DESCRIPTION>5/17/10 SALE
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-05-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>MEDIVATION, INC.</issuerName>
        <issuerTradingSymbol>MDVN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001423327</rptOwnerCik>
            <rptOwnerName>PALEKAR ROHAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>201 SPEAR STREET, THIRD FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Commercial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-05-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>10.908</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7500</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares sold pursuant to a 10b5-1 Plan.</footnote>
        <footnote id="F2">The shares were sold at prices between $10.89 and $10.92.  The Reporting Person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares old at each separate price.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ C. Patrick Machado, Attorney-in-fact</signatureName>
        <signatureDate>2010-05-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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