-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TzCtJfYy+g4RHaTfVbd+kS20jGhViCvXro7v2h+/T78aDikJ0rcceG5TCUoyVPbZ
 UEEji1lPpepAoT3q9yB2CA==

<SEC-DOCUMENT>0001181431-07-062919.txt : 20071018
<SEC-HEADER>0001181431-07-062919.hdr.sgml : 20071018
<ACCEPTANCE-DATETIME>20071018192435
ACCESSION NUMBER:		0001181431-07-062919
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071001
FILED AS OF DATE:		20071018
DATE AS OF CHANGE:		20071018

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIVATION, INC.
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105
		BUSINESS PHONE:		415-543-3470

	MAIL ADDRESS:	
		STREET 1:		201 SPEAR STREET, 3RD FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORION ACQUISITION CORP II
		DATE OF NAME CHANGE:	19960408

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Seely Lynn
		CENTRAL INDEX KEY:			0001327111

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32836
		FILM NUMBER:		071179759

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(415) 543-3470

	MAIL ADDRESS:	
		STREET 1:		501 2ND STREET
		STREET 2:		SUITE 211
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd175365.xml
<DESCRIPTION>L. SEELEY OPTION GRANT 10/1/07
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-10-01</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>MEDIVATION, INC.</issuerName>
        <issuerTradingSymbol>MDVN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001327111</rptOwnerCik>
            <rptOwnerName>Seely Lynn</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MEDIVATION, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>201 SPEAR STREET, 3RD FLOOR</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Medical Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>21.17</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2007-10-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>150000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2017-10-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>150000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>150000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.60</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-03-14</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>333000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>333000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The shares subject to the option shall become vested according to the following schedule:  25% of the shares subject to the option (rounded down to the next whole number of shares) shall vest on October 1, 2008, and 1/48 of the shares subject to the option (rounded down to the next whole number of shares) shall vest on the first day of each full month thereafter, so that all of the shares subject to the option shall become fully vested on October 1, 2011.</footnote>
        <footnote id="F2">This option is immediately exercisable, in whole or in part, and the shares subject to the option vest according to the following schedule:  25% of the shares subject to the option vested on March 14, 2006, and 1/48 of the shares subject to the option vested and continue to vest on the first day of each full month thereafter, so that all of the shares subject to the option shall be fully vested on March 1, 2009.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>C. Patrick Machado, Attorney-in-Fact for Lynn Seely, M.D.</signatureName>
        <signatureDate>2007-10-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----