-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 CyYayXgMrSSzui8hIc4XM5pVl+XK4OQtD+Dig26ym/tVykdw0xoljXjT7aa2HsdV
 BfdWiFUHNQqFz8cvyOBPmQ==

<SEC-DOCUMENT>0001181431-06-006516.txt : 20060130
<SEC-HEADER>0001181431-06-006516.hdr.sgml : 20060130
<ACCEPTANCE-DATETIME>20060130180147
ACCESSION NUMBER:		0001181431-06-006516
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051231
FILED AS OF DATE:		20060130
DATE AS OF CHANGE:		20060130

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GORLIN STEVE
		CENTRAL INDEX KEY:			0001033742

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-20837
		FILM NUMBER:		06563388

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		3012179858

	MAIL ADDRESS:	
		STREET 1:		150 GULF SHORE DRIVE
		STREET 2:		UNIT 601
		CITY:			DESTIN
		STATE:			FL
		ZIP:			32541

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIVATION, INC.
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		501 SECOND STREET
		STREET 2:		SUITE 211
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
		BUSINESS PHONE:		415-543-3470

	MAIL ADDRESS:	
		STREET 1:		501 SECOND STREET
		STREET 2:		SUITE 211
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORION ACQUISITION CORP II
		DATE OF NAME CHANGE:	19960408
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>rrd102963.xml
<DESCRIPTION>DARA CHANGE IN TYPE OF OWNERSHIP
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2005-12-31</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>MEDIVATION, INC.</issuerName>
        <issuerTradingSymbol>MDVN.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001033742</rptOwnerCik>
            <rptOwnerName>GORLIN STEVE</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MEDIVATION, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>501 SECOND STREET, SUITE 211</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94107</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionCoding></transactionCoding>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>233780</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Trust</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionCoding></transactionCoding>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>759093</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares represent a pro rata distribution from Dara BioSciences, Inc., of which the reporting person is Chairman of the Board and a principal stockholder.  As such, in prior reports the reporting person reported indirect beneficial ownership of an aggregate of 2,657,317 shares of Medivation, Inc. common stock held by Dara BioSciences, Inc.</footnote>
        <footnote id="F2">Shares held by the Steve Gorlin Revocable Trust u/i/d May19, 1998, of which the reporting person is the trustee and beneficiary.</footnote>
        <footnote id="F3">Represents post-distribution net securities held by Dara BioSciences, Inc., of which the reporting person is Chairman of the Board of Directors and principal stockholder.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>C. Patrick Machado, Attorney-In-Fact for Steve Gorlin</signatureName>
        <signatureDate>2006-01-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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