-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 NYcskXzU1Now6dct9j92Wpor5RO+qS5hwN5Mf/LwGS2C3LtFZGDCQulcjOcsmyZc
 QfJgy1Ke6pnFU6eNFf78Vw==

<SEC-DOCUMENT>0001181431-05-035703.txt : 20050620
<SEC-HEADER>0001181431-05-035703.hdr.sgml : 20050617
<ACCEPTANCE-DATETIME>20050620192920
ACCESSION NUMBER:		0001181431-05-035703
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050520
FILED AS OF DATE:		20050620
DATE AS OF CHANGE:		20050620

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Bailey Gregory
		CENTRAL INDEX KEY:			0001329505

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-20837
		FILM NUMBER:		05906845

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		310-526-5000

	MAIL ADDRESS:	
		STREET 1:		401 WILSHIRE BLVD. STE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORION ACQUISITION CORP II
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	BLANK CHECKS [6770]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401
		BUSINESS PHONE:		310-526-5000

	MAIL ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd81923.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-05-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>ORION ACQUISITION CORP II</issuerName>
        <issuerTradingSymbol>MTMR.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001329505</rptOwnerCik>
            <rptOwnerName>Bailey Gregory</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MEDIVATION, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>501 SECOND STREET, SUITE 211</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94107</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>214508</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>80000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.55</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <value>2009-12-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>214508</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents securities held by 703149 Ontario Inc., of which the Reporting Person is the principal stockholder and executive officer.</footnote>
        <footnote id="F2">Represents securities held by Topix, Inc., of which the Reporting Person is the principal stockholder and executive officer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ C. Patrick Machado, Attorney-In-Fact for Gregory H. Bailey, M.D.</signatureName>
        <signatureDate>2005-06-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----