-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-05-031909.txt : 20050611
<SEC-HEADER>0001181431-05-031909.hdr.sgml : 20050611
<ACCEPTANCE-DATETIME>20050531191728
ACCESSION NUMBER:		0001181431-05-031909
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050520
FILED AS OF DATE:		20050531
DATE AS OF CHANGE:		20050531

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GORLIN STEVE
		CENTRAL INDEX KEY:			0001033742

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-20837
		FILM NUMBER:		05868757

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		3012179858

	MAIL ADDRESS:	
		STREET 1:		150 GULF SHORE DRIVE
		STREET 2:		UNIT 601
		CITY:			DESTIN
		STATE:			FL
		ZIP:			32541

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORION ACQUISITION CORP II
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	BLANK CHECKS [6770]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401
		BUSINESS PHONE:		310-526-5000

	MAIL ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd80891.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-05-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>ORION ACQUISITION CORP II</issuerName>
        <issuerTradingSymbol>MTMR.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001033742</rptOwnerCik>
            <rptOwnerName>GORLIN STEVE</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ORION ACQUISITION CORP. II</rptOwnerStreet1>
            <rptOwnerStreet2>501 SECOND STREET, SUITE 211</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94107</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>444487</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <value>2013-10-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>129032</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-04-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>32258</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2212830</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents securities held by Dara BioSciences, Inc., of which the Reporting Person is the Chairman of the Board of Directors and a principal stockholder. Issued to Dara BioSciences, Inc. in exchange for shares of capital stock of Medivation, Inc. (&quot;Medivation&quot;) held by Dara BioSciences, Inc. in connection with the merger by and between Orion Acquisition Corp. II (&quot;Orion&quot;), Medivation Acquisition Corp. (&quot;Merger Sub&quot;) and Medivation, pursuant to which Merger Sub, a wholly-owned subsidiary of Orion, was merged with and into Medivation, and Medivation became a wholly-owned subsidiary of Orion.  Each share of the Series B Convertible Preferred Stock will be automatically converted into twenty (20) shares of Common Stock upon the occurrence of certain events; and the warrants held by Dara Biosciences, Inc. are exercisable to purchase an aggregate of 161,290 shares of Common Stock at an exercise price of $1.55 per share.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>C. Patrick Machado, Attorney-In-Fact for Steve Gorlin</signatureName>
        <signatureDate>2005-05-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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