-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 VJanDXDSYXA6cso2KnXxfcNROtGyhJYtHAtp/w8IEuPy6Klhv1H5pPdEJBQolblf
 1AHDD/TSTabSoLdjbL8f6Q==

<SEC-DOCUMENT>0001181431-04-060179.txt : 20041221
<SEC-HEADER>0001181431-04-060179.hdr.sgml : 20041221
<ACCEPTANCE-DATETIME>20041221170342
ACCESSION NUMBER:		0001181431-04-060179
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20041217
FILED AS OF DATE:		20041221
DATE AS OF CHANGE:		20041221

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORION ACQUISITION CORP II
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	BLANK CHECKS [6770]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401
		BUSINESS PHONE:		310-526-5000

	MAIL ADDRESS:	
		STREET 1:		401 WILSHIRE BOULEVARD
		STREET 2:		SUITE 1020
		CITY:			SANTA MONICA
		STATE:			CA
		ZIP:			90401

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DARA BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001277298

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-20837
		FILM NUMBER:		041218140

	BUSINESS ADDRESS:	
		STREET 1:		1234 AIRPORT ROAD
		STREET 2:		SUITE 105
		CITY:			DESTIN
		STATE:			FL
		ZIP:			32541
		BUSINESS PHONE:		850-650-1010
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd62125.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-12-17</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>ORION ACQUISITION CORP II</issuerName>
        <issuerTradingSymbol>MTMR.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001277298</rptOwnerCik>
            <rptOwnerName>DARA BIOSCIENCES INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1234 AIRPORT ROAD</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 109</rptOwnerStreet2>
            <rptOwnerCity>DESTIN</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>32541</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2212830</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2004-12-17</value>
            </exerciseDate>
            <expirationDate>
                <value>2013-10-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>161290</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Not Applicable</footnote>
        <footnote id="F2">Issued to the reporting person in exchange for shares of capital stock of Medivation, Inc. (&quot;Medivation&quot;) held by the reporting person in connection with the merger by and between Orion Acquisition Corp. II (&quot;Orion&quot;), Medivation Acquisition Corp. (&quot;Merger Sub&quot;) and Medivation, pursuant to which Merger Sub, a wholly-owned subsidiary of Orion, was merged with and into Medivation, and Medivation became a wholly-owned subsidiary of Orion.  Each share of the Series B Convertible Preferred Stock will be automatically converted into twenty (20) shares of Common Stock upon the occurrence of certain events.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John C. Thomas, Chief Financial Officer of DARA BioSciences, Inc.</signatureName>
        <signatureDate>2004-12-21</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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