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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0000000000-05-019420.txt : 20060524
<SEC-HEADER>0000000000-05-019420.hdr.sgml : 20060524
<ACCEPTANCE-DATETIME>20050420162301
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0000000000-05-019420
CONFORMED SUBMISSION TYPE:	UPLOAD
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20050420

FILED FOR:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIVATION, INC.
		CENTRAL INDEX KEY:			0001011835
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133863260
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		UPLOAD

	BUSINESS ADDRESS:	
		STREET 1:		501 SECOND STREET
		STREET 2:		SUITE 211
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
		BUSINESS PHONE:		415-543-3470

	MAIL ADDRESS:	
		STREET 1:		501 SECOND STREET
		STREET 2:		SUITE 211
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORION ACQUISITION CORP II
		DATE OF NAME CHANGE:	19960408
</SEC-HEADER>
<DOCUMENT>
<TYPE>LETTER
<SEQUENCE>1
<FILENAME>filename1.txt
<TEXT>


Mail Stop 0511


							April 20, 2005


C. Patrick Machado
Senior Vice President and Chief Financial Officer
Orion Acquisition Corp. II
501 Second Street, Suite 211
San Francisco, California 94107

		RE:	Orion Acquisition Corp. II
			Registration Statement on Form SB-2
			File No. 333-122431

Dear Mr. Machado:

      After consideration of the company`s supplemental response
and
discussion with counsel, we reissue our prior comment 1 of our
letter
dated February 25, 2005.  Your offering appears to be an "at the
market" primary offering of equity securities by or on behalf of
the
registrant under Rule 415(a)(4) of Regulation C.  Because you do
not
qualify to conduct a primary offering "at the market," please
revise
the terms of your offering to provide that all offers and sales
will
be made at a disclosed fixed price for the duration of the
offering,
resales will be made on a prompt and continuous basis, and the
selling shareholders will be identified as underwriters.  You may
contact Jay Ingram at (202) 942-2791 if you any questions.

      Sincerely,


John Reynolds
Assistant Director
      Office of Emerging Growth Companies


cc.	John Huber, Esq.
	202-637-3374
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1


</TEXT>
</DOCUMENT>
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