The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 1,171 5,579 SH   SOLE   5,579 0 0
ABBVIE INC COM COM 00287Y109 16,376 184,285 SH   SOLE   178,050 0 6,235
ACADIA PHARMACEUTICALS INC COM 004225108 203 5,400 SH   SOLE   5,400 0 0
ACCENTURE PLC COM g1151c101 219 1,624 SH   SOLE   299 0 1,325
ADVAXIS INC COM 007624208 250 59,800 SH   SOLE   59,800 0 0
AFLAC INC COM COM 001055102 3,102 38,112 SH   SOLE   35,772 0 2,340
AIMMUNE THERAPEUTICS INC COM 00900t107 283 11,420 SH   SOLE   1,420 0 10,000
ALIBABA GROUP LTD SPR ADR COM 01609w102 651 3,767 SH   SOLE   3,767 0 0
ALLIANCE DATA SYSTEM CORP COM 018581108 4,958 22,379 SH   SOLE   22,184 0 195
ALPHABET INC CAP STK CL A COM 02079k305 1,436 1,475 SH   SOLE   1,275 0 200
ALPHABET INC CAP STK CL C COM 02079k107 16,172 16,861 SH   SOLE   16,485 0 376
ALTRIA GROUP INC COM 02209s103 340 5,355 SH   SOLE   5,355 0 0
AMAZON.COM INC COM 023135106 11,091 11,537 SH   SOLE   11,454 0 83
AMER ELEC PWR INC COM COM 025537101 343 4,890 SH   SOLE   4,890 0 0
AMERICAN EAGLE OUTFITTERS COM 02553e106 143 10,000 SH   SOLE   10,000 0 0
AMERICAN EXPRESS CO COM COM 025816109 5,182 57,290 SH   SOLE   57,290 0 0
AMGEN INC COM COM 031162100 504 2,701 SH   SOLE   1,701 0 1,000
APPLE INC COM COM 037833100 27,447 178,090 SH   SOLE   171,218 0 6,872
ARALEZ PHARMACEUTICALS INC COM 03852x100 227 99,229 SH   SOLE   15,329 0 83,900
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,747 44,612 SH   SOLE   43,093 0 1,519
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 531 20,962 SH   SOLE   20,962 0 0
BB & T COM 054937107 1,505 32,071 SH   SOLE   30,969 0 1,102
BELLLICUM PHARMACEUTICALS INC COM 079481107 142 12,285 SH   SOLE   7,285 0 5,000
BERKSHIRE HATHAWAY-CL A COM 084670108 275 1 SH   SOLE   1 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 5,484 29,914 SH   SOLE   26,494 0 3,420
BIOCRYST PHARMACEUTICALS COM 09058v103 257 49,000 SH   SOLE   49,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BITZIO INC. COM 091751107 0 20,000 SH   SOLE   20,000 0 0
BLACK STONE MINERALS LP COM 09225m101 486 28,000 SH   SOLE   28,000 0 0
BLACKHAWK NETWORK HOLDINGS COM 09238e104 482 11,007 SH   SOLE   11,007 0 0
BLACKROCK INC COM COM 09247X101 15,014 33,581 SH   SOLE   32,665 0 916
BOEING CO COM 097023105 1,566 6,162 SH   SOLE   6,162 0 0
BORG WARNER AUTOMOTIVE INC COM 099724106 2,364 46,140 SH   SOLE   45,240 0 900
BRISTOLMYERS SQUIBB COM 110122108 7,054 110,668 SH   SOLE   110,023 0 645
BRITISH AMERICAN TOB SP ADR RE COM 110448107 203 3,257 SH   SOLE   2,962 0 295
CALITHERA BIOSCIENCES, INC. COM 13089p101 560 35,580 SH   SOLE   15,580 0 20,000
CAPITAL ONE FINANCIAL COM 14040h105 339 4,000 SH   SOLE   4,000 0 0
CATERPILLAR INC COM 149123101 836 6,700 SH   SOLE   6,700 0 0
CEMPRA INC COM 15130j109 210 64,550 SH   SOLE   24,550 0 40,000
CHEVRON CORPORATION COM 166764100 9,275 78,939 SH   SOLE   75,174 0 3,765
CISCO SYS INC COM COM 17275R102 17,022 506,149 SH   SOLE   494,179 0 11,970
CLOROX COMPANY COM 189054109 4,176 31,657 SH   SOLE   31,047 0 610
CME GROUP INC COM COM 12572Q105 22,303 164,380 SH   SOLE   159,095 0 5,285
COACH INC COM 189754104 7,353 182,558 SH   SOLE   172,323 0 10,235
COCA COLA COMPANY COM 191216100 8,748 194,358 SH   SOLE   184,283 0 10,075
COMCASTCORP NEW CL A COM 20030n101 7,860 204,268 SH   SOLE   192,368 0 11,900
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 357 7,135 SH   SOLE   7,135 0 0
CORE LABS COM N22717107 7,535 76,345 SH   SOLE   75,675 0 670
COSTCO WHOLESALE COM 22160k105 401 2,440 SH   SOLE   2,440 0 0
DANAHER CORP COM COM 235851102 9,646 112,445 SH   SOLE   111,215 0 1,230
DEPOMED INC COM 249908104 116 20,000 SH   SOLE   10,000 0 10,000
DISNEY WALT CO COM 254687106 9,556 96,941 SH   SOLE   93,491 0 3,450
DOMINION RES INC VA NEW COM 25746u109 335 4,360 SH   SOLE   4,360 0 0
DOWDUPONT INC COM 26078j100 9,294 134,248 SH   SOLE   129,828 0 4,420
DUKE ENERGY CORPORATION NEW COM 26441c204 1,584 18,872 SH   SOLE   17,489 0 1,383
EBAY INC COM COM 278642103 291 7,555 SH   SOLE   3,005 0 4,550
ECOLAB INC COM COM 278865100 250 1,940 SH   SOLE   1,725 0 215
ENBRIDGE INC COM 29250n105 690 16,486 SH   SOLE   10,371 0 6,115
EOG RESOURCES INC COM 26875p101 8,012 82,818 SH   SOLE   81,893 0 925
EXTENDED STAY AMERICA INC COM 30224p200 5,697 284,835 SH   SOLE   271,435 0 13,400
EXXON MOBIL CORP COM COM 30231G102 4,711 57,470 SH   SOLE   53,732 0 3,738
FACEBOOK COM 30303m102 12,207 71,440 SH   SOLE   70,705 0 735
FEDEXCORP COM 31428x106 400 1,775 SH   SOLE   275 0 1,500
FIBROCELL SCIENCE INC NEW COM 315721308 51 16,667 SH   SOLE   0 0 16,667
FIBROGEN INC COM 31572q808 538 10,000 SH   SOLE   0 0 10,000
FIRST BANCORP NORTH CAROLINA COM 318910106 349 10,131 SH   SOLE   10,131 0 0
FLOWERS FOODS INC COM 343498101 1,050 55,800 SH   SOLE   55,800 0 0
FORTIVE CORP COM COM 34959j108 5,143 72,655 SH   SOLE   71,929 0 726
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 6,964 103,592 SH   SOLE   102,582 0 1,010
GENERAL DYNAMICS CRP COM 369550108 1,236 6,010 SH   SOLE   4,270 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 1,863 77,052 SH   SOLE   66,662 0 10,390
GENERAL MOTORS COM 37045v100 580 14,358 SH   SOLE   12,581 0 1,777
GILEAD SCIENCES INC COM COM 375558103 8,575 105,835 SH   SOLE   102,330 0 3,505
GOLDMAN SACHS GROUP INC COM 38141g104 2,540 10,710 SH   SOLE   9,935 0 775
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HEAT BIOLOGICS INC COM 42237K102 40 60,500 SH   SOLE   50,500 0 10,000
HERSHEY FOODS COM 427866108 14,720 134,839 SH   SOLE   130,059 0 4,780
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 177 12,050 SH   SOLE   12,050 0 0
HOME DEPOT INC COM COM 437076102 5,902 36,087 SH   SOLE   35,772 0 315
HONEYWELL INTERNATIONAL INC CO COM 438516106 10,241 72,251 SH   SOLE   70,331 0 1,920
HP, INC. COM 40434l105 241 12,050 SH   SOLE   12,050 0 0
IDEXX LABORATORIES COM 45168d104 6,685 42,990 SH   SOLE   42,695 0 295
ILLINOIS TOOL WORKS COM 452308109 592 4,000 SH   SOLE   4,000 0 0
INCYTE GENOMICS INC COM 45337c102 467 4,000 SH   SOLE   4,000 0 0
INSMED INC COM 457669307 493 15,800 SH   SOLE   15,800 0 0
INTEL CORP COM 458140100 880 23,107 SH   SOLE   23,107 0 0
INTL BUSINESS MACHINES COM 459200101 6,041 41,641 SH   SOLE   39,526 0 2,115
INTRA CELLULAR THERAPIES INC COM 46116x101 253 16,060 SH   SOLE   1,060 0 15,000
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,776 18,965 SH   SOLE   18,965 0 0
JAZZ PHARMACEUTICALS PLC COM g50871105 502 3,430 SH   SOLE   3,430 0 0
JOHNSON & JOHNSON COM 478160104 10,769 82,831 SH   SOLE   78,746 0 4,085
JPMORGAN CHASE & CO COM 46625h100 15,195 159,097 SH   SOLE   152,070 0 7,027
KINDER MORGAN INC COM 49456b101 1,519 79,176 SH   SOLE   69,176 0 10,000
KKR & CO LP COM 48248m102 353 17,375 SH   SOLE   17,375 0 0
KRAFT HEINZ CO. COM 500754106 5,866 75,644 SH   SOLE   71,754 0 3,890
LABORATORY CRP OF AMER HLDGS COM 50540r409 7,553 50,032 SH   SOLE   49,517 0 515
LINCOLN NATIONAL CORP COM 534187109 420 5,713 SH   SOLE   5,713 0 0
LOCKHEED MARTIN CORP COM 539830109 7,802 25,143 SH   SOLE   24,088 0 1,055
LOWE'S COS COM 548661107 353 4,410 SH   SOLE   4,410 0 0
LYONDELLBASELL INDUSTRIES NV O COM n53745100 7,478 75,499 SH   SOLE   71,904 0 3,595
MARRIOTT INTL NEW COM 571903202 6,619 60,035 SH   SOLE   59,550 0 485
MARTIN MARIETTA MATERIALS INC COM 573284106 7,566 36,685 SH   SOLE   36,315 0 370
MATTEL INC COM 577081102 232 15,000 SH   SOLE   15,000 0 0
MC DONALDS CORP COM 580135101 7,419 47,353 SH   SOLE   45,886 0 1,467
MERCK & CO INC NEW COM 58933y105 7,478 116,784 SH   SOLE   108,931 0 7,853
METLIFE INC COM 59156r108 7,859 151,285 SH   SOLE   145,490 0 5,795
MICROSOFT CORP COM 594918104 20,433 274,307 SH   SOLE   261,377 0 12,930
MONDELEZ INTL INC COM COM 609207105 6,800 167,243 SH   SOLE   165,803 0 1,440
MONSANTO CO COM 61166w101 9,324 77,815 SH   SOLE   75,715 0 2,100
NEKTAR THERAPEUTICS COM 640268108 1,392 58,000 SH   SOLE   58,000 0 0
NIKE INC CL B COM 654106103 4,501 86,809 SH   SOLE   85,974 0 835
NORFOLK SOUTHERN CORP COM 655844108 1,942 14,685 SH   SOLE   14,685 0 0
NORTHROP GRUMMAN CORP COM 666807102 210 730 SH   SOLE   730 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 141 20,000 SH   SOLE   20,000 0 0
NVIDIA CORP COM 67066g104 370 2,067 SH   SOLE   2,067 0 0
ORACLE CORP COM COM 68389X105 3,393 70,179 SH   SOLE   61,559 0 8,620
PARK STERLING COM 70086y105 191 15,384 SH   SOLE   15,384 0 0
PAYCHEX INC COM 704326107 6,473 107,957 SH   SOLE   101,342 0 6,615
PAYPAL HOLDINGS INC COM 70450y103 13,672 213,518 SH   SOLE   209,033 0 4,485
PDL BIOPHARMA INC COM 69329y104 76 22,500 SH   SOLE   20,000 0 2,500
PEPSICO INCORPORATED COM 713448108 6,598 59,213 SH   SOLE   56,228 0 2,985
PFIZER INC COM 717081103 1,158 32,425 SH   SOLE   32,425 0 0
PHILIP MORRIS INTL INC COM 718172109 783 7,049 SH   SOLE   7,049 0 0
PHILLIPS 66 COM 718546104 363 3,966 SH   SOLE   3,966 0 0
PHOENIX METALS CORP COM 71910b204 1 10,000 SH   SOLE   10,000 0 0
PNC BK CORP COM COM 693475105 249 1,848 SH   SOLE   248 0 1,600
PROCTER & GAMBLE COM 742718109 1,742 19,148 SH   SOLE   16,228 0 2,920
PROTAGONIST THERAPEUTICS INC COM 74366E102 295 16,700 SH   SOLE   6,700 0 10,000
PUMA BIOTECHNOLOGY INC COM 74587v107 2,635 22,000 SH   SOLE   0 0 22,000
QUALCOMM INC COM COM 747525103 599 11,547 SH   SOLE   11,547 0 0
RAYONIER INC COM COM 754907103 217 7,500 SH   SOLE   7,500 0 0
REPLIGEN CORP COM 759916109 383 10,000 SH   SOLE   10,000 0 0
RIGEL PHARMACEUTICALS COM 766559603 51 20,000 SH   SOLE   20,000 0 0
ROYAL BANK OF CANADA COM 780087102 5,203 67,272 SH   SOLE   63,482 0 3,790
ROYAL DUTCH SHELL PLC SPON ADR COM 780259206 212 3,500 SH   SOLE   1,500 0 2,000
S&P GLOBAL INC COM 78409v104 229 1,466 SH   SOLE   1,466 0 0
SABINE ROYALTY TRUST UBI COM 785688102 816 20,000 SH   SOLE   20,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 848 56,500 SH   SOLE   16,500 0 40,000
SCHLUMBERGER LTD COM COM 806857108 1,452 20,821 SH   SOLE   18,871 0 1,950
SCRIPSAMERICA INC COM COM 811066109 0 10,000 SH   SOLE   10,000 0 0
SNAP ON TOOLS CORP COM 833034101 2,209 14,825 SH   SOLE   14,660 0 165
SOUTHERN CO COM 842587107 6,997 142,383 SH   SOLE   136,538 0 5,845
STANDARD & POOR'S DEP RCPTS COM 78462f103 3,829 15,243 SH   SOLE   13,743 0 1,500
STRYKER CORP COM 863667101 398 2,800 SH   SOLE   800 0 2,000
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,176 29,400 SH   SOLE   29,400 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 49 52,000 SH   SOLE   0 0 52,000
TARGET CORPORATION COM 87612e106 236 4,000 SH   SOLE   4,000 0 0
THERMO FISHER CORP COM COM 883556102 4,043 21,369 SH   SOLE   20,999 0 370
TRIMBLE INC. COM 896239100 3,844 97,945 SH   SOLE   97,080 0 865
UNION BANK COM 90520v103 5,068 320,752 SH   SOLE   320,752 0 0
UNITED HEALTHCARE CORP COM 91324p102 230 1,175 SH   SOLE   100 0 1,075
UNITED PARCEL SERVICE - CL B COM 911312106 258 2,149 SH   SOLE   349 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 8,939 77,009 SH   SOLE   76,299 0 710
V F CORP COM 918204108 5,261 82,757 SH   SOLE   79,112 0 3,645
VERIZON COMMUNICATIONS COM 92343v104 8,342 168,562 SH   SOLE   162,594 0 5,968
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   SOLE   11,000 0 0
WASTE MANAGEMENT INC DEL COM 94106l109 7,532 96,228 SH   SOLE   91,813 0 4,415
WELLS FARGO & CO NEW COM 949746101 1,317 23,880 SH   SOLE   23,880 0 0
WILLIAMS CO INC COM 969457100 240 8,000 SH   SOLE   5,000 0 3,000
YUM BRANDS INC COM 988498101 6,608 89,765 SH   SOLE   88,915 0 850
ZOETIS INC COM 98978v103 245 3,846 SH   SOLE   3,846 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 361 10,000 SH   SOLE   10,000 0 0
VANGUARD FTSE ALL-WORLD ex-US ADR 922042775 211 4,000 SH   SOLE   4,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 200,000 SH   SOLE   200,000 0 0
QLT INC WTS WT 746992189 0 200,000 SH   SOLE   200,000 0 0