SIGA Technologies, Inc. 

660 Madison Avenue
New York, NY 10065

October 20, 2016

VIA EDGAR

Securities and Exchange Commission 

Division of Corporation Finance 

100 F Street, N.E. 

Washington, D.C. 20549

Attention: Suzanne Hayes

Re: SIGA Technologies, Inc. (the “Registrant”)
Registration Statement on Form S-1 (File No. 333-211866)

Dear Ms. Hayes:

The undersigned hereby respectfully requests that, pursuant to Rule 461 under the Securities Act of 1933, as amended, the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated so that it will become effective on Friday, October 21, 2016 at 9:00 a.m. (E.S.T.), or as soon thereafter as is practicable.

The undersigned, on behalf of the Registrant, hereby acknowledges that:

· should the Securities & Exchange Commission (the “Commission”) or the Staff thereof (the “Staff”), acting pursuant to delegated authority, declare this filing effective, it does not foreclose the Commission from taking any action with respect to the filing;

· the action of the Commission or the Staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Registrant from its full responsibility for the adequacy and accuracy of the disclosure of the filing; and

· the Registrant may not assert Staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Please contact James Grayer of Kramer Levin Naftalis & Frankel LLP, outside counsel to the Registrant, at (212) 715-7616 upon the Registration Statement becoming effective.

Very truly yours,
SIGA Technologies, Inc.
By:	/s/ Daniel J. Luckshire
	Name: Daniel J. Luckshire
	Title: EVP & CFO