The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 49,056 | 2,149,702 | SH | DFND | 1 | 2,149,702 | 0 | 0 | |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 26,255 | 1,029,410 | SH | DFND | 1 | 1,029,410 | 0 | 0 | |
| ACURA PHARMACEUTICALS INC | COM PAR $0.01 | 00509L802 | 1,897 | 1,025,641 | SH | DFND | 1 | 1,025,641 | 0 | 0 | |
| ADEPTUS HEALTH INC | CL A | 006855100 | 82,700 | 1,600,861 | SH | DFND | 1 | 1,600,861 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 44,362 | 2,520,585 | SH | DFND | 1 | 2,520,585 | 0 | 0 | |
| AETNA INC NEW | COM | 00817Y108 | 44,700 | 366,000 | SH | DFND | 1 | 366,000 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,903 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 15,523 | 1,150,700 | SH | DFND | 1 | 1,150,700 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 4,804 | 1,069,914 | SH | DFND | 1 | 1,069,914 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,524 | 267,764 | SH | DFND | 1 | 267,764 | 0 | 0 | |
| ALIMERA SCIENCES INC | COM | 016259103 | 7,230 | 5,878,015 | SH | DFND | 1 | 5,878,015 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 18,645 | 336,000 | SH | DFND | 1 | 336,000 | 0 | 0 | |
| ALPHATEC HOLDINGS INC | COM | 02081G102 | 1,745 | 4,982,738 | SH | DFND | 1 | 4,982,738 | 0 | 0 | |
| AMAG PHARMACEUTICALS INC | NOTE 2.500% 2/1 | 00163UAA4 | 7,161 | 6,500,000 | PRN | DFND | 1 | 6,500,000 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 5,427 | 1,644,583 | SH | DFND | 1 | 1,644,583 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 2,401 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 29,765 | 8,361,069 | SH | DFND | 1 | 8,361,069 | 0 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 37,815 | 45,000,000 | PRN | DFND | 1 | 45,000,000 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 85,039 | 2,236,701 | SH | DFND | 1 | 2,236,701 | 0 | 0 | |
| AXOGEN INC | COM | 05463X106 | 23,264 | 3,381,439 | SH | DFND | 1 | 3,381,439 | 0 | 0 | |
| BIOSCRIP INC | COM | 09069N108 | 7,616 | 2,986,800 | SH | DFND | 1 | 2,986,800 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 14,636 | 338,085 | SH | DFND | 1 | 338,085 | 0 | 0 | |
| CAREDX INC | COM | 14167L103 | 221 | 51,204 | SH | DFND | 1 | 51,204 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 5,888 | 3,200,000 | SH | DFND | 1 | 3,200,000 | 0 | 0 | |
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 2,381 | 643,580 | SH | DFND | 1 | 643,580 | 0 | 0 | |
| CIGNA CORPORATION | COM | 125509109 | 21,886 | 171,000 | SH | DFND | 1 | 171,000 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 2,326 | 169,506 | SH | DFND | 1 | 169,506 | 0 | 0 | |
| CORSICANTO LTD | NOTE 3.500% 1/1 | 220480AB3 | 1,021 | 1,000,000 | PRN | DFND | 1 | 1,000,000 | 0 | 0 | |
| COTIVITI HLDGS INC | COM | 22164K101 | 19,019 | 900,079 | SH | DFND | 1 | 900,079 | 0 | 0 | |
| CYNAPSUS THERAPEUTICS INC | COM PAR NO PAR | 23257Y859 | 818 | 48,840 | SH | DFND | 1 | 48,840 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 9,637 | 943,433 | SH | DFND | 1 | 943,433 | 0 | 0 | |
| DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 40,593 | 525,000 | SH | DFND | 1 | 525,000 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 56,864 | 1,743,229 | SH | DFND | 1 | 1,743,229 | 0 | 0 | |
| EDITAS MEDICINE INC | COM | 28106W103 | 41,709 | 1,709,400 | SH | DFND | 1 | 1,709,400 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 805 | 162,288 | SH | DFND | 1 | 162,288 | 0 | 0 | |
| EHEALTH INC | COM | 28238P109 | 37,021 | 2,640,609 | SH | DFND | 1 | 2,640,609 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 468 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| ENDOCHOICE HLDGS INC | COM | 29272U103 | 5,875 | 1,198,950 | SH | DFND | 1 | 1,198,950 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 37,787 | 40,941,000 | PRN | DFND | 1 | 40,941,000 | 0 | 0 | |
| EPIZYME INC | COM | 29428V104 | 6,372 | 622,299 | SH | DFND | 1 | 622,299 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 6,364 | 2,157,151 | SH | DFND | 1 | 2,157,151 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 18,525 | 448,000 | SH | DFND | 1 | 448,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 43,742 | 4,072,809 | SH | DFND | 1 | 4,072,809 | 0 | 0 | |
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 16,658 | 27,715,000 | PRN | DFND | 1 | 27,715,000 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 8,141 | 1,282,058 | SH | DFND | 1 | 1,282,058 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 25,411 | 458,112 | SH | DFND | 1 | 458,112 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 2,818 | 687,257 | SH | DFND | 1 | 687,257 | 0 | 0 | |
| GLAUKOS CORP | COM | 377322102 | 28,697 | 984,112 | SH | DFND | 1 | 984,112 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 28,764 | 1,733,828 | SH | DFND | 1 | 1,733,828 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 90,819 | 991,800 | SH | DFND | 1 | 991,800 | 0 | 0 | |
| HEALTHWAYS INC | COM | 422245100 | 29,356 | 2,541,686 | SH | DFND | 1 | 2,541,686 | 0 | 0 | |
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 72,000 | 76,925,000 | PRN | DFND | 1 | 76,925,000 | 0 | 0 | |
| HEARTWARE INTL INC | NOTE 1.750%12/1 | 422368AC4 | 29,939 | 30,271,000 | PRN | DFND | 1 | 30,271,000 | 0 | 0 | |
| HEARTWARE INTL INC | NOTE 3.500%12/1 | 422368AA8 | 39,689 | 40,226,000 | PRN | DFND | 1 | 40,226,000 | 0 | 0 | |
| HORIZON PHARMA INVT LTD | NOTE 2.500% 3/1 | 44052TAB7 | 75,166 | 82,600,000 | PRN | DFND | 1 | 82,600,000 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 226,302 | 13,740,261 | SH | DFND | 1 | 13,740,261 | 0 | 0 | |
| HUMANA INC | COM | 444859102 | 28,691 | 159,500 | SH | DFND | 1 | 159,500 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 7,278 | 91,000 | SH | DFND | 1 | 91,000 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 2,575 | 1,935,942 | SH | DFND | 1 | 1,935,942 | 0 | 0 | |
| INNOCOLL HLDGS PLC | SHS | G4783X105 | 1,669 | 302,923 | SH | DFND | 1 | 302,923 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 12,646 | 1,327,009 | SH | DFND | 1 | 1,327,009 | 0 | 0 | |
| KEMPHARM INC | COM | 488445107 | 5,654 | 1,420,497 | SH | DFND | 1 | 1,420,497 | 0 | 0 | |
| LANNET INC | COM | 516012101 | 21,306 | 895,591 | SH | DFND | 1 | 895,591 | 0 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 5,818 | 251,000 | SH | DFND | 1 | 251,000 | 0 | 0 | |
| MOLINA HEALTHCARE INC | COM | 60855R100 | 21,756 | 436,000 | SH | DFND | 1 | 436,000 | 0 | 0 | |
| MYLAN N V | SHS EURO | N59465109 | 57,913 | 1,339,334 | SH | DFND | 1 | 1,339,334 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 4,648 | 374,800 | SH | DFND | 1 | 374,800 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 8,500 | 674,622 | SH | DFND | 1 | 674,622 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 4,253 | 458,332 | SH | DFND | 1 | 458,332 | 0 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 17,169 | 3,732,412 | SH | DFND | 1 | 3,732,412 | 0 | 0 | |
| NXSTAGE MEDICAL INC | COM | 67072V103 | 97,679 | 4,505,468 | SH | DFND | 1 | 4,505,468 | 0 | 0 | |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 1,088 | 572,893 | SH | DFND | 1 | 572,893 | 0 | 0 | |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 4,181 | 464,541 | SH | DFND | 1 | 464,541 | 0 | 0 | |
| PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 444 | 63,072 | SH | DFND | 1 | 63,072 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 1,687 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 1,391 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 86,700 | 3,673,727 | SH | DFND | 1 | 3,673,727 | 0 | 0 | |
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 3,201 | 1,608,702 | SH | DFND | 1 | 1,608,702 | 0 | 0 | |
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 12,463 | 1,552,031 | SH | DFND | 1 | 1,552,031 | 0 | 0 | |
| PSIVIDA CORP | COM | 74440J101 | 4,225 | 1,492,824 | SH | DFND | 1 | 1,492,824 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 9,352 | 1,169,042 | SH | DFND | 1 | 1,169,042 | 0 | 0 | |
| RELYPSA INC | COM | 759531106 | 30,902 | 1,670,383 | SH | DFND | 1 | 1,670,383 | 0 | 0 | |
| RENNOVA HEALTH INC | *W EXP 12/30/202 | 759757115 | 27 | 645,161 | SH | DFND | 1 | 645,161 | 0 | 0 | |
| RENNOVA HEALTH INC | COM | 759757107 | 111 | 176,425 | SH | DFND | 1 | 176,425 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 5,199 | 2,331,366 | SH | DFND | 1 | 2,331,366 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 19,561 | 2,611,580 | SH | DFND | 1 | 2,611,580 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 3,848 | 1,773,177 | SH | DFND | 1 | 1,773,177 | 0 | 0 | |
| SELECT MED HLDGS CORP | COM | 81619Q105 | 14,315 | 1,316,944 | SH | DFND | 1 | 1,316,944 | 0 | 0 | |
| SPARK THERAPEUTICS INC | COM | 84652J103 | 18,816 | 368,000 | SH | DFND | 1 | 368,000 | 0 | 0 | |
| SPECTRANETICS CORP | MTNF 2.625% 6/0 | 84760CAA5 | 11,232 | 12,731,000 | PRN | DFND | 1 | 12,731,000 | 0 | 0 | |
| STEADYMED LTD | SHS | M84920103 | 4,404 | 1,346,744 | SH | DFND | 1 | 1,346,744 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 796 | 662,971 | SH | DFND | 1 | 662,971 | 0 | 0 | |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 38,028 | 2,095,220 | SH | DFND | 1 | 2,095,220 | 0 | 0 | |
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 1,641 | 2,583,160 | SH | DFND | 1 | 2,583,160 | 0 | 0 | |
| TRACON PHARMACEUTICALS INC | COM | 89237H100 | 296 | 67,567 | SH | DFND | 1 | 67,567 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 1,547 | 172,307 | SH | DFND | 1 | 172,307 | 0 | 0 | |
| TRINITY BIOTECH INVT LTD | NOTE 4.000% 4/0 | 89643QAB4 | 43,935 | 48,000,000 | PRN | DFND | 1 | 48,000,000 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 32,768 | 4,323,000 | SH | DFND | 1 | 4,323,000 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 67,103 | 5,996,691 | SH | DFND | 1 | 5,996,691 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 2,586 | 235,294 | SH | DFND | 1 | 235,294 | 0 | 0 | |
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 50,916 | 611,457 | SH | DFND | 1 | 611,457 | 0 | 0 | |
| WRIGHT MED GROUP INC | NOTE 2.000% 2/1 | 98235TAE7 | 36,749 | 40,050,000 | PRN | DFND | 1 | 40,050,000 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 55,650 | 2,930,486 | SH | DFND | 1 | 2,930,486 | 0 | 0 | |
| XENOPORT INC | COM | 98411C100 | 81,468 | 11,572,125 | SH | DFND | 1 | 11,572,125 | 0 | 0 | |
| ZAFGEN INC | COM | 98885E103 | 18,303 | 3,055,603 | SH | DFND | 1 | 3,055,603 | 0 | 0 | |
| ZELTIQ AESTHETICS INC | COM | 98933Q108 | 35,447 | 1,297,000 | SH | DFND | 1 | 1,297,000 | 0 | 0 | |