The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   495,771 4,674 SH   DFND 1 4,674 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   281,037 8,821 SH   DFND 1 8,821 0 0
ABSCI CORPORATION COM 00091E109   269,465 47,441 SH   DFND 1 47,441 0 0
ACCOLADE INC COM 00437E102   24,964,429 2,382,102 SH   DFND 1 2,382,102 0 0
ACCOLADE INC NOTE 0.500% 4/0 00437EAB8   117,481,828 132,598,000 PRN   DFND 1 132,598,000 0 0
ACUTUS MED INC COM 005111109   500,232 2,660,808 SH   DFND 1 2,660,808 0 0
ADAPTHEALTH CORP COMMON STOCK 00653Q102   152,598,889 13,257,940 SH   DFND 1 13,257,940 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   209,571 65,287 SH   DFND 1 65,287 0 0
ADMA BIOLOGICS INC COM 000899104   535,946 81,204 SH   DFND 1 81,204 0 0
ADOBE INC COM 00724F101   516,710 1,024 SH   DFND 1 1,024 0 0
AGILON HEALTH INC COM 00857U107   415,001 68,033 SH   DFND 1 68,033 0 0
AGILYSYS INC COM 00847J105   673,996 7,999 SH   DFND 1 7,999 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   516,320 17,658 SH   DFND 1 17,658 0 0
AKEBIA THERAPEUTICS INC COM 00972D105   86,193 47,100 SH   DFND 1 47,100 0 0
AKERO THERAPEUTICS INC COM 00973Y108   344,673 13,645 SH   DFND 1 13,645 0 0
ALBANY INTL CORP CL A 012348108   301,476 3,224 SH   DFND 1 3,224 0 0
ALECTOR INC COM 014442107   6,458,527 1,072,845 SH   DFND 1 1,072,845 0 0
ALIGN TECHNOLOGY INC COM 016255101   300,047 915 SH   DFND 1 915 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104   41,022,657 8,270,697 SH   DFND 1 8,270,697 0 0
ALPHABET INC CAP STK CL A 02079K305   248,129 1,644 SH   DFND 1 1,644 0 0
ALPHATEC HLDGS INC COM NEW 02081G201   139,775 10,136 SH   DFND 1 10,136 0 0
ALTA EQUIPMENT GROUP INC COMMON STOCK 02128L106   438,047 33,826 SH   DFND 1 33,826 0 0
ALTRIA GROUP INC COM 02209S103   468,435 10,739 SH   DFND 1 10,739 0 0
AMAZON COM INC COM 023135106   941,403 5,219 SH   DFND 1 5,219 0 0
AMC NETWORKS INC CL A 00164V103   337,687 27,839 SH   DFND 1 27,839 0 0
AMEDISYS INC COM 023436108   643,092 6,978 SH   DFND 1 6,978 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106   305,766 11,856 SH   DFND 1 11,856 0 0
AMERICAN VANGUARD CORP COM 030371108   232,206 17,931 SH   DFND 1 17,931 0 0
AMERICAS CAR-MART INC COM 03062T105   254,011 3,977 SH   DFND 1 3,977 0 0
AMERICOLD REALTY TRUST INC COM 03064D108   348,755 13,995 SH   DFND 1 13,995 0 0
AMERISAFE INC COM 03071H100   282,608 5,633 SH   DFND 1 5,633 0 0
AMICUS THERAPEUTICS INC COM 03152W109   194,240 16,489 SH   DFND 1 16,489 0 0
AMPLIFY ENERGY CORP NEW COM 03212B103   528,833 80,005 SH   DFND 1 80,005 0 0
ANGIODYNAMICS INC COM 03475V101   273,489 46,591 SH   DFND 1 46,591 0 0
ANI PHARMACEUTICALS INC COM 00182C103   319,865 4,627 SH   DFND 1 4,627 0 0
ANNEXON INC COM 03589W102   4,186,656 583,913 SH   DFND 1 583,913 0 0
ANSYS INC COM 03662Q105   484,288 1,395 SH   DFND 1 1,395 0 0
API GROUP CORP COM STK 00187Y100   874,307 22,264 SH   DFND 1 22,264 0 0
APOGEE THERAPEUTICS INC COM 03770N101   21,862,050 329,000 SH   DFND 1 329,000 0 0
APPLE INC COM 037833100   591,435 3,449 SH   DFND 1 3,449 0 0
APTIV PLC SHS G6095L109   555,798 6,978 SH   DFND 1 6,978 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   334,106 33,714 SH   DFND 1 33,714 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101   306,386 2,304 SH   DFND 1 2,304 0 0
ARIS WATER SOLUTIONS INC CLASS A COM 04041L106   203,760 14,400 SH   DFND 1 14,400 0 0
ARS PHARMACEUTICALS INC COM 82835W108   113,216,414 11,077,927 SH   DFND 1 11,077,927 0 0
AT&T INC COM 00206R102   342,162 19,441 SH   DFND 1 19,441 0 0
ATRICURE INC COM 04963C209   630,911 20,740 SH   DFND 1 20,740 0 0
ATRION CORP COM 049904105   505,270 1,090 SH   DFND 1 1,090 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   23,216,820 3,639,000 SH   DFND 1 3,639,000 0 0
AVID BIOSERVICES INC COM 05368M106   681,986 101,789 SH   DFND 1 101,789 0 0
AVIDXCHANGE HOLDINGS INC COM 05368X102   345,806 26,297 SH   DFND 1 26,297 0 0
AXCELIS TECHNOLOGIES INC COM NEW 054540208   665,663 5,969 SH   DFND 1 5,969 0 0
AZZ INC COM 002474104   459,299 5,941 SH   DFND 1 5,941 0 0
B & G FOODS INC NEW COM 05508R106   349,160 30,521 SH   DFND 1 30,521 0 0
BAIN CAP SPECIALTY FIN INC COM STK 05684B107   397,582 25,356 SH   DFND 1 25,356 0 0
BARINGS BDC INC COM 06759L103   463,335 49,821 SH   DFND 1 49,821 0 0
BAXTER INTL INC COM 071813109   262,466 6,141 SH   DFND 1 6,141 0 0
BECTON DICKINSON & CO COM 075887109   465,701 1,882 SH   DFND 1 1,882 0 0
BELLRING BRANDS INC COMMON STOCK 07831C103   374,486 6,344 SH   DFND 1 6,344 0 0
BERKLEY W R CORP COM 084423102   269,300 3,045 SH   DFND 1 3,045 0 0
BERRY CORP COM 08579X101   118,246 14,689 SH   DFND 1 14,689 0 0
BEST BUY INC COM 086516101   530,078 6,462 SH   DFND 1 6,462 0 0
BIO RAD LABS INC CL A 090572207   52,702,979 152,378 SH   DFND 1 152,378 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   25,374,600 4,995,000 SH   DFND 1 4,995,000 0 0
BIOMX INC COM 09090D103   2,749,544 6,110,098 SH   DFND 1 6,110,098 0 0
BIONTECH SE SPONSORED ADS 09075V102   52,543,202 569,574 SH   DFND 1 569,574 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101   526,221 6,956 SH   DFND 1 6,956 0 0
BLACKSTONE SECD LENDING FD COMMON STOCK 09261X102   413,423 13,272 SH   DFND 1 13,272 0 0
BLUE OWL CAPITAL CORPORATION COM 69121K104   564,984 36,735 SH   DFND 1 36,735 0 0
BLUE OWL CAPITAL INC COM CL A 09581B103   786,688 41,712 SH   DFND 1 41,712 0 0
BOEING CO COM 097023105   407,016 2,109 SH   DFND 1 2,109 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100   377,716 3,332 SH   DFND 1 3,332 0 0
BRIGHTHOUSE FINL INC COM 10922N103   387,581 7,520 SH   DFND 1 7,520 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   291,215 5,370 SH   DFND 1 5,370 0 0
BROOKDALE SR LIVING INC COM 112463104   103,197,065 15,612,264 SH   DFND 1 15,612,264 0 0
BROOKDALE SR LIVING INC NOTE 2.000%10/1 112463AC8   158,406,233 161,905,000 PRN   DFND 1 161,905,000 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110   33,073 733,333 SH   DFND 1 733,333 0 0
C4 THERAPEUTICS INC COM STK 12529R107   233,580 28,590 SH   DFND 1 28,590 0 0
CABALETTA BIO INC COM 12674W109   21,472,569 1,258,650 SH   DFND 1 1,258,650 0 0
CALAVO GROWERS INC COM 128246105   294,063 10,574 SH   DFND 1 10,574 0 0
CALCIMEDICA INC COM NEW 38942Q202   4,160,000 1,000,000 SH   DFND 1 1,000,000 0 0
CAMPBELL SOUP CO COM 134429109   253,409 5,701 SH   DFND 1 5,701 0 0
CARDINAL HEALTH INC COM 14149Y108   254,684 2,276 SH   DFND 1 2,276 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   11,491 672,000 SH   DFND 1 672,000 0 0
CAREMAX INC CL A NEW 14171W202   2,550,301 529,108 SH   DFND 1 529,108 0 0
CARMAX INC COM 143130102   209,674 2,407 SH   DFND 1 2,407 0 0
CARRIAGE SVCS INC COM 143905107   486,152 17,979 SH   DFND 1 17,979 0 0
CARTERS INC COM 146229109   316,957 3,743 SH   DFND 1 3,743 0 0
CASTLE BIOSCIENCES INC COM 14843C105   20,555,577 928,017 SH   DFND 1 928,017 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101   145,545,223 9,130,817 SH   DFND 1 9,130,817 0 0
CENTENE CORP DEL COM 15135B101   186,864,333 2,381,044 SH   DFND 1 2,381,044 0 0
CERUS CORP COM 157085101   112,714 59,637 SH   DFND 1 59,637 0 0
CG ONCOLOGY INC COM 156944100   2,087,006 47,540 SH   DFND 1 47,540 0 0
CHART INDS INC COM 16115Q308   612,758 3,720 SH   DFND 1 3,720 0 0
CHEWY INC CL A 16679L109   525,348 33,020 SH   DFND 1 33,020 0 0
CNO FINL GROUP INC COM 12621E103   354,904 12,915 SH   DFND 1 12,915 0 0
COGENT BIOSCIENCES INC COM 19240Q201   10,310,798 1,534,345 SH   DFND 1 1,534,345 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104   311,142 8,015 SH   DFND 1 8,015 0 0
COLUMBIA SPORTSWEAR CO COM 198516106   342,255 4,216 SH   DFND 1 4,216 0 0
CONFLUENT INC CLASS A COM 20717M103   273,520 8,962 SH   DFND 1 8,962 0 0
CONMED CORP COM 207410101   27,080,253 338,165 SH   DFND 1 338,165 0 0
CONSOLIDATED EDISON INC COM 209115104   297,403 3,275 SH   DFND 1 3,275 0 0
COOPER COS INC COM 216648501   521,809 5,143 SH   DFND 1 5,143 0 0
CORNING INC COM 219350105   488,368 14,817 SH   DFND 1 14,817 0 0
CORTEVA INC COM 22052L104   291,695 5,058 SH   DFND 1 5,058 0 0
CULLINAN ONCOLOGY INC COM 230031106   19,400,568 1,138,531 SH   DFND 1 1,138,531 0 0
CUSTOMERS BANCORP INC COM 23204G100   227,999 4,297 SH   DFND 1 4,297 0 0
CYTOKINETICS INC COM NEW 23282W605   404,114 5,764 SH   DFND 1 5,764 0 0
DARDEN RESTAURANTS INC COM 237194105   1,058,895 6,335 SH   DFND 1 6,335 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   29,162,954 1,765,312 SH   DFND 1 1,765,312 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   80,651,957 5,127,270 SH   DFND 1 5,127,270 0 0
DEERE & CO COM 244199105   353,236 860 SH   DFND 1 860 0 0
DELUXE CORP COM 248019101   368,252 17,885 SH   DFND 1 17,885 0 0
DENTSPLY SIRONA INC COM 24906P109   255,231 7,690 SH   DFND 1 7,690 0 0
DISC MEDICINE INC COM 254604101   41,436,209 665,535 SH   DFND 1 665,535 0 0
DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107   207,053 84,168 SH   DFND 1 84,168 0 0
DOCGO INC COM 256086109   20,621,723 5,104,387 SH   DFND 1 5,104,387 0 0
DUPONT DE NEMOURS INC COM 26614N102   384,960 5,021 SH   DFND 1 5,021 0 0
DXC TECHNOLOGY CO COM 23355L106   1,320,216 62,245 SH   DFND 1 62,245 0 0
DYNE THERAPEUTICS INC COM 26818M108   225,417 7,940 SH   DFND 1 7,940 0 0
ECOLAB INC COM 278865100   255,606 1,107 SH   DFND 1 1,107 0 0
ECOVYST INC COM 27923Q109   258,870 23,217 SH   DFND 1 23,217 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   52,432,449 2,874,586 SH   DFND 1 2,874,586 0 0
ELECTRONIC ARTS INC COM 285512109   875,887 6,602 SH   DFND 1 6,602 0 0
EMBECTA CORP COMMON STOCK 29082K105   36,175,811 2,726,135 SH   DFND 1 2,726,135 0 0
EMPLOYERS HLDGS INC COM 292218104   518,672 11,427 SH   DFND 1 11,427 0 0
ENHABIT INC COM 29332G102   58,223,741 4,997,746 SH   DFND 1 4,997,746 0 0
ENGENE HOLDINGS INC COM 29286M105   13,560,000 800,000 SH   DFND 1 800,000 0 0
ENLINK MIDSTREAM LLC COM UNIT REP LTD 29336T100   235,549 17,269 SH   DFND 1 17,269 0 0
ENVESTNET INC COM 29404K106   573,599 9,905 SH   DFND 1 9,905 0 0
ESAB CORPORATION COM 29605J106   392,081 3,546 SH   DFND 1 3,546 0 0
EXELIXIS INC COM 30161Q104   208,349 8,780 SH   DFND 1 8,780 0 0
EXPONENT INC COM 30214U102   229,382 2,774 SH   DFND 1 2,774 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   11,980,208 579,594 SH   DFND 1 579,594 0 0
FASTENAL CO COM 311900104   228,874 2,967 SH   DFND 1 2,967 0 0
FASTLY INC CL A 31188V100   461,174 35,557 SH   DFND 1 35,557 0 0
FATE THERAPEUTICS INC COM 31189P102   16,077,595 2,190,408 SH   DFND 1 2,190,408 0 0
FIVE BELOW INC COM 33829M101   404,840 2,232 SH   DFND 1 2,232 0 0
FLOWSERVE CORP COM 34354P105   587,308 12,857 SH   DFND 1 12,857 0 0
FLUSHING FINL CORP COM 343873105   508,057 40,290 SH   DFND 1 40,290 0 0
FORTINET INC COM 34959E109   616,225 9,021 SH   DFND 1 9,021 0 0
FRACTYL HEALTH INC COM 35168W103   6,173,480 834,254 SH   DFND 1 834,254 0 0
FRESHWORKS INC CLASS A COM 358054104   292,016 16,036 SH   DFND 1 16,036 0 0
FTI CONSULTING INC COM 302941109   681,760 3,242 SH   DFND 1 3,242 0 0
FUELCELL ENERGY INC COM 35952H601   92,395 77,643 SH   DFND 1 77,643 0 0
FULGENT GENETICS INC COM 359664109   237,810 10,959 SH   DFND 1 10,959 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   136,469,320 6,401,000 SH   DFND 1 6,401,000 0 0
GALAPAGOS NV SPON ADR 36315X101   45,434,200 1,411,000 SH   DFND 1 1,411,000 0 0
GENEDX HOLDINGS CORP COM CL A 81663L200   5,871,594 643,110 SH   DFND 1 643,110 0 0
GENERAL MTRS CO COM 37045V100   397,901 8,774 SH   DFND 1 8,774 0 0
GENESCO INC COM 371532102   556,778 19,786 SH   DFND 1 19,786 0 0
GENTHERM INC COM 37253A103   319,972 5,557 SH   DFND 1 5,557 0 0
GINKGO BIOWORKS HOLDINGS INC CL A SHS 37611X100   40,563 34,968 SH   DFND 1 34,968 0 0
GLOBE LIFE INC COM 37959E102   391,352 3,363 SH   DFND 1 3,363 0 0
GOLUB CAP BDC INC COM 38173M102   553,779 33,300 SH   DFND 1 33,300 0 0
GOPRO INC CL A 38268T103   390,582 175,149 SH   DFND 1 175,149 0 0
GROUP 1 AUTOMOTIVE INC COM 398905109   294,276 1,007 SH   DFND 1 1,007 0 0
GUARDANT HEALTH INC COM 40131M109   16,333,493 791,735 SH   DFND 1 791,735 0 0
GUESS INC COM 401617105   510,632 16,226 SH   DFND 1 16,226 0 0
HAIN CELESTIAL GROUP INC COM 405217100   199,196 25,343 SH   DFND 1 25,343 0 0
HALOZYME THERAPEUTICS INC COM 40637H109   449,189 11,042 SH   DFND 1 11,042 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   282,744 8,420 SH   DFND 1 8,420 0 0
HARROW INC COM 415858109   216,205 16,342 SH   DFND 1 16,342 0 0
HCI GROUP INC COM 40416E103   386,546 3,330 SH   DFND 1 3,330 0 0
HEALTH CATALYST INC COM 42225T107   110,789 14,713 SH   DFND 1 14,713 0 0
HEALTHCARE SVCS GROUP INC COM 421906108   574,529 46,036 SH   DFND 1 46,036 0 0
HEALTHEQUITY INC COM 42226A107   380,396 4,660 SH   DFND 1 4,660 0 0
HEXCEL CORP NEW COM 428291108   383,118 5,259 SH   DFND 1 5,259 0 0
HILLEVAX INC COM 43157M102   66,590,362 4,004,231 SH   DFND 1 4,004,231 0 0
HIMS & HERS HEALTH INC COM CL A 433000106   162,760 10,521 SH   DFND 1 10,521 0 0
HONEST CO INC COM 438333106   441,320 108,968 SH   DFND 1 108,968 0 0
HURON CONSULTING GROUP INC COM 447462102   387,929 4,015 SH   DFND 1 4,015 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   115,417,213 2,630,292 SH   DFND 1 2,630,292 0 0
IHEARTMEDIA INC COM CL A 45174J509   274,944 131,552 SH   DFND 1 131,552 0 0
ILLINOIS TOOL WKS INC COM 452308109   662,775 2,470 SH   DFND 1 2,470 0 0
IMMERSION CORP COM 452521107   342,778 45,826 SH   DFND 1 45,826 0 0
IMMUNOME INC COM 45257U108   568,405 23,031 SH   DFND 1 23,031 0 0
INCYTE CORP COM 45337C102   380,104 6,672 SH   DFND 1 6,672 0 0
INGERSOLL RAND INC COM 45687V106   480,922 5,065 SH   DFND 1 5,065 0 0
INMODE LTD SHS M5425M103   25,212,473 1,166,704 SH   DFND 1 1,166,704 0 0
INNODATA INC COM NEW 457642205   180,213 27,305 SH   DFND 1 27,305 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7   124,394,613 116,954,000 PRN   DFND 1 116,954,000 0 0
INSULET CORP COM 45784P101   18,864,455 110,061 SH   DFND 1 110,061 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208   52,221,041 1,473,090 SH   DFND 1 1,473,090 0 0
INTEGRA LIFESCIENCES HLDGS C NOTE 0.500% 8/1 457985AM1   98,735,469 103,215,000 PRN   DFND 1 103,215,000 0 0
INVENTRUST PPTYS CORP COM NEW 46124J201   372,024 14,470 SH   DFND 1 14,470 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106   313,432 2,702 SH   DFND 1 2,702 0 0
ITEOS THERAPEUTICS INC COM 46565G104   9,861,720 723,000 SH   DFND 1 723,000 0 0
ITT INC COM 45073V108   513,377 3,774 SH   DFND 1 3,774 0 0
JACOBS SOLUTIONS INC COM 46982L108   372,334 2,422 SH   DFND 1 2,422 0 0
JANUS INTERNATIONAL GROUP IN COMMON STOCK 47103N106   280,495 18,539 SH   DFND 1 18,539 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   182,087 15,353 SH   DFND 1 15,353 0 0
KELLY SVCS INC CL A 488152208   377,178 15,063 SH   DFND 1 15,063 0 0
KEURIG DR PEPPER INC COM 49271V100   200,306 6,531 SH   DFND 1 6,531 0 0
KIMBERLY-CLARK CORP COM 494368103   541,330 4,185 SH   DFND 1 4,185 0 0
KKR & CO INC COM 48251W104   488,517 4,857 SH   DFND 1 4,857 0 0
KOHLS CORP COM 500255104   478,206 16,405 SH   DFND 1 16,405 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207   212,785 11,577 SH   DFND 1 11,577 0 0
KURA ONCOLOGY INC COM 50127T109   115,428,809 5,411,571 SH   DFND 1 5,411,571 0 0
KYVERNA THERAPEUTICS INC COM 501976104   36,324,451 1,462,337 SH   DFND 1 1,462,337 0 0
LANTHEUS HLDGS INC COM 516544103   14,949,239 240,187 SH   DFND 1 240,187 0 0
LANTHEUS HLDGS INC NOTE 2.625%12/1 516544AB9   28,020,928 25,255,000 PRN   DFND 1 25,255,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100   161,150,683 21,231,974 SH   DFND 1 21,231,974 0 0
LEIDOS HOLDINGS INC COM 525327102   361,546 2,758 SH   DFND 1 2,758 0 0
LEMAITRE VASCULAR INC COM 525558201   449,257 6,770 SH   DFND 1 6,770 0 0
LEONARDO DRS INC COM 52661A108   704,406 31,888 SH   DFND 1 31,888 0 0
LIFE TIME GROUP HOLDINGS INC COMMON STOCK 53190C102   348,610 22,462 SH   DFND 1 22,462 0 0
LIFEMD INC COM 53216B104   329,834 32,085 SH   DFND 1 32,085 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   271,828 18,429 SH   DFND 1 18,429 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   207,878 9,624 SH   DFND 1 9,624 0 0
LTC PPTYS INC COM 502175102   221,653 6,818 SH   DFND 1 6,818 0 0
MAIN STR CAP CORP COM 56035L104   452,094 9,556 SH   DFND 1 9,556 0 0
MANNKIND CORP COM NEW 56400P706   757,769 167,278 SH   DFND 1 167,278 0 0
MANPOWERGROUP INC WIS COM 56418H100   600,235 7,731 SH   DFND 1 7,731 0 0
MARATHON DIGITAL HOLDINGS IN COM 565788106   332,355 14,719 SH   DFND 1 14,719 0 0
MARVELL TECHNOLOGY INC COM 573874104   261,335 3,687 SH   DFND 1 3,687 0 0
MASTERBRAND INC COMMON STOCK 57638P104   240,434 12,830 SH   DFND 1 12,830 0 0
MATIV HOLDINGS INC COM 808541106   363,450 19,384 SH   DFND 1 19,384 0 0
MATTHEWS INTL CORP CL A 577128101   386,573 12,438 SH   DFND 1 12,438 0 0
MAXIMUS INC COM 577933104   205,723 2,452 SH   DFND 1 2,452 0 0
MBIA INC COM 55262C100   161,267 23,856 SH   DFND 1 23,856 0 0
MERCURY GENL CORP NEW COM 589400100   323,274 6,265 SH   DFND 1 6,265 0 0
MERSANA THERAPEUTICS INC COM 59045L106   257,501 57,478 SH   DFND 1 57,478 0 0
MERUS N V COM N5749R100   119,302,527 2,649,401 SH   DFND 1 2,649,401 0 0
METLIFE INC COM 59156R108   218,402 2,947 SH   DFND 1 2,947 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105   235,638 177 SH   DFND 1 177 0 0
MICRON TECHNOLOGY INC COM 595112103   447,628 3,797 SH   DFND 1 3,797 0 0
MKS INSTRS INC COM 55306N104   309,358 2,326 SH   DFND 1 2,326 0 0
MODERNA INC COM 60770K107   249,031 2,337 SH   DFND 1 2,337 0 0
MORGAN STANLEY COM NEW 617446448   257,433 2,734 SH   DFND 1 2,734 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307   205,888 580 SH   DFND 1 580 0 0
MPLX LP COM UNIT REP LTD 55336V100   452,672 10,892 SH   DFND 1 10,892 0 0
MSA SAFETY INC COM 553498106   439,836 2,272 SH   DFND 1 2,272 0 0
MUELLER WTR PRODS INC COM SER A 624758108   328,156 20,395 SH   DFND 1 20,395 0 0
N-ABLE INC COMMON STOCK 62878D100   757,485 57,956 SH   DFND 1 57,956 0 0
NATIONAL RESH CORP COM NEW 637372202   356,252 8,994 SH   DFND 1 8,994 0 0
NEOGENOMICS INC NOTE 1.250% 5/0 64049MAA8   6,293,885 6,500,000 PRN   DFND 1 6,500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   95,303,272 691,004 SH   DFND 1 691,004 0 0
NEVRO CORP COM 64157F103   175,229 12,135 SH   DFND 1 12,135 0 0
NEW YORK TIMES CO CL A 650111107   344,204 7,964 SH   DFND 1 7,964 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109   15,774,550 667,000 SH   DFND 1 667,000 0 0
NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 N62509117   1,024,368 92,787 SH   DFND 1 92,787 0 0
NGL ENERGY PARTNERS LP COM UNIT REPST 62913M107   246,701 42,830 SH   DFND 1 42,830 0 0
NKARTA INC COM 65487U108   56,148,080 5,194,087 SH   DFND 1 5,194,087 0 0
NORDSTROM INC COM 655664100   202,112 9,971 SH   DFND 1 9,971 0 0
NORTHERN TR CORP COM 665859104   407,431 4,582 SH   DFND 1 4,582 0 0
NORTHWEST BANCSHARES INC MD COM 667340103   434,161 37,267 SH   DFND 1 37,267 0 0
NURIX THERAPEUTICS INC COM 67080M103   242,800 16,517 SH   DFND 1 16,517 0 0
NUVALENT INC COM 670703107   1,501,125,992 19,991,024 SH   DFND 1 19,991,024 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119   50,416 166,666 SH   DFND 1 166,666 0 0
NVIDIA CORPORATION COM 67066G104   857,478 949 SH   DFND 1 949 0 0
OCULAR THERAPEUTIX INC COM 67576A100   289,853 31,852 SH   DFND 1 31,852 0 0
OLD REP INTL CORP COM 680223104   290,212 9,447 SH   DFND 1 9,447 0 0
OLYMPIC STEEL INC COM 68162K106   439,031 6,194 SH   DFND 1 6,194 0 0
OMEGA HEALTHCARE INVS INC COM 681936100   309,986 9,788 SH   DFND 1 9,788 0 0
OMNICELL COM COM 68213N109   271,839 9,300 SH   DFND 1 9,300 0 0
ORACLE CORP COM 68389X105   370,550 2,950 SH   DFND 1 2,950 0 0
ORASURE TECHNOLOGIES INC COM 68554V108   176,843 28,755 SH   DFND 1 28,755 0 0
OSCAR HEALTH INC CL A 687793109   139,377,952 9,373,097 SH   DFND 1 9,373,097 0 0
OWENS & MINOR INC NEW COM 690732102   135,157,963 4,877,588 SH   DFND 1 4,877,588 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108   353,204 15,350 SH   DFND 1 15,350 0 0
PARSONS CORP DEL COM 70202L102   486,087 5,860 SH   DFND 1 5,860 0 0
PATHWARD FINANCIAL INC COM 59100U108   312,370 6,188 SH   DFND 1 6,188 0 0
PAYONEER GLOBAL INC COM 70451X104   77,634 15,974 SH   DFND 1 15,974 0 0
PAYPAL HLDGS INC COM 70450Y103   416,343 6,215 SH   DFND 1 6,215 0 0
PENNYMAC MTG INVT TR COM 70931T103   593,145 40,405 SH   DFND 1 40,405 0 0
PENSKE AUTOMOTIVE GRP INC COM 70959W103   625,119 3,859 SH   DFND 1 3,859 0 0
PEPSICO INC COM 713448108   334,094 1,909 SH   DFND 1 1,909 0 0
PERSPECTIVE THERAPEUTICS INC COM 46489V104   33,531,387 28,177,636 SH   DFND 1 28,177,636 0 0
PHARVARIS N V COM N69605108   24,533,391 1,061,592 SH   DFND 1 1,061,592 0 0
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106   160,759 12,433 SH   DFND 1 12,433 0 0
POLARIS INC COM 731068102   796,955 7,960 SH   DFND 1 7,960 0 0
PRELUDE THERAPEUTICS INC COM 74065P101   19,590,420 4,133,000 SH   DFND 1 4,133,000 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101   491,812 6,778 SH   DFND 1 6,778 0 0
PRIME MEDICINE INC COM 74168J101   6,197,198 885,314 SH   DFND 1 885,314 0 0
PROASSURANCE CORP COM 74267C106   345,484 26,865 SH   DFND 1 26,865 0 0
PROGRESS SOFTWARE CORP COM 743312100   1,033,894 19,394 SH   DFND 1 19,394 0 0
PROGYNY INC COM 74340E103   255,910 6,708 SH   DFND 1 6,708 0 0
PULMONX CORP COM 745848101   188,079 20,289 SH   DFND 1 20,289 0 0
QUANTUM SI INC *W EXP 06/10/202 74765K113   80,733 333,333 SH   DFND 1 333,333 0 0
QUEST DIAGNOSTICS INC COM 74834L100   287,118 2,157 SH   DFND 1 2,157 0 0
QUIDELORTHO CORP COM 219798105   16,683,120 348,000 SH   DFND 1 348,000 0 0
R1 RCM INC COM 77634L105   601,316 46,686 SH   DFND 1 46,686 0 0
RADNET INC COM 750491102   314,441 6,462 SH   DFND 1 6,462 0 0
RALPH LAUREN CORP CL A 751212101   357,307 1,903 SH   DFND 1 1,903 0 0
RAMACO RES INC COM CL A 75134P600   320,027 19,004 SH   DFND 1 19,004 0 0
REPAY HLDGS CORP COM CL A 76029L100   477,829 43,439 SH   DFND 1 43,439 0 0
REPLIMUNE GROUP INC COM 76029N106   6,560,379 802,984 SH   DFND 1 802,984 0 0
REVOLUTION MEDICINES INC COM 76155X100   99,593,053 3,090,073 SH   DFND 1 3,090,073 0 0
REVVITY INC COM 714046109   421,365 4,013 SH   DFND 1 4,013 0 0
RITHM CAPITAL CORP COM NEW 64828T201   232,396 20,824 SH   DFND 1 20,824 0 0
RXSIGHT INC COM 78349D107   422,182 8,185 SH   DFND 1 8,185 0 0
SABRE CORP COM 78573M104   111,276 45,982 SH   DFND 1 45,982 0 0
SANDRIDGE ENERGY INC COM NEW 80007P869   328,976 22,579 SH   DFND 1 22,579 0 0
SENTINELONE INC CL A 81730H109   210,326 9,023 SH   DFND 1 9,023 0 0
SERVICE CORP INTL COM 817565104   585,888 7,895 SH   DFND 1 7,895 0 0
SIMPLY GOOD FOODS CO COM 82900L102   311,068 9,141 SH   DFND 1 9,141 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   2,563,221 4,984,871 SH   DFND 1 4,984,871 0 0
SKYWATER TECHNOLOGY INC COM 83089J108   727,969 71,580 SH   DFND 1 71,580 0 0
SKYWORKS SOLUTIONS INC COM 83088M102   585,686 5,407 SH   DFND 1 5,407 0 0
SLR INVESTMENT CORP COM 83413U100   208,591 13,589 SH   DFND 1 13,589 0 0
SOLARIS OILFIELD INFRASTRUCT COM CL A 83418M103   437,644 50,478 SH   DFND 1 50,478 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   30,108,501 2,260,398 SH   DFND 1 2,260,398 0 0
SONOCO PRODS CO COM 835495102   584,473 10,105 SH   DFND 1 10,105 0 0
SONOS INC COM 83570H108   313,194 16,432 SH   DFND 1 16,432 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   63,157,923 1,283,176 SH   DFND 1 1,283,176 0 0
STANDARD BIOTOOLS INC COM 34385P108   211,624 78,090 SH   DFND 1 78,090 0 0
STATE STR CORP COM 857477103   306,728 3,967 SH   DFND 1 3,967 0 0
STERICYCLE INC COM 858912108   603,302 11,437 SH   DFND 1 11,437 0 0
STIFEL FINL CORP COM 860630102   258,977 3,313 SH   DFND 1 3,313 0 0
STOCK YDS BANCORP INC COM 861025104   480,345 9,821 SH   DFND 1 9,821 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   44,303,525 1,033,680 SH   DFND 1 1,033,680 0 0
SUNRUN INC COM 86771W105   188,724 14,319 SH   DFND 1 14,319 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   226,968 6,654 SH   DFND 1 6,654 0 0
SURGERY PARTNERS INC COM 86881A100   95,062,333 3,186,803 SH   DFND 1 3,186,803 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   5,033 166,666 SH   DFND 1 166,666 0 0
SUTRO BIOPHARMA INC COM 869367102   95,626 16,925 SH   DFND 1 16,925 0 0
TANGO THERAPEUTICS INC COM 87583X109   12,227,600 1,540,000 SH   DFND 1 1,540,000 0 0
TARGA RES CORP COM 87612G101   363,632 3,247 SH   DFND 1 3,247 0 0
TD SYNNEX CORPORATION COM 87162W100   812,963 7,188 SH   DFND 1 7,188 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105   419,016 976 SH   DFND 1 976 0 0
TERADATA CORP DEL COM 88076W103   351,974 9,102 SH   DFND 1 9,102 0 0
TERNS PHARMACEUTICALS INC COM 880881107   157,834 24,060 SH   DFND 1 24,060 0 0
TERRENO RLTY CORP COM 88146M101   328,946 4,954 SH   DFND 1 4,954 0 0
TETRA TECHNOLOGIES INC DEL COM 88162F105   338,071 76,314 SH   DFND 1 76,314 0 0
THE BEAUTY HEALTH COMPANY COM CL A 88331L108   283,427 63,835 SH   DFND 1 63,835 0 0
THE ONCOLOGY INSTITUTE INC COM 68236X100   5,308,882 3,360,052 SH   DFND 1 3,360,052 0 0
THE ONCOLOGY INSTITUTE INC *W EXP 99/99/999 68236X118   250,000 1,250,000 SH   DFND 1 1,250,000 0 0
TIPTREE INC COM 88822Q103   289,060 16,728 SH   DFND 1 16,728 0 0
TRAVELERS COMPANIES INC COM 89417E109   287,905 1,251 SH   DFND 1 1,251 0 0
TRINITY INDS INC COM 896522109   259,813 9,329 SH   DFND 1 9,329 0 0
TRISALUS LIFE SCIENCES INC COM 89680M101   10 1 SH   DFND 1 1 0 0
TRISALUS LIFE SCIENCES INC *W EXP 08/10/202 89680M119   333,300 333,333 SH   DFND 1 333,333 0 0
ULTA BEAUTY INC COM 90384S303   492,030 941 SH   DFND 1 941 0 0
UNITEDHEALTH GROUP INC COM 91324P102   242,403 490 SH   DFND 1 490 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100   494,467 2,710 SH   DFND 1 2,710 0 0
URBAN EDGE PPTYS COM 91704F104   258,895 14,991 SH   DFND 1 14,991 0 0
USANA HEALTH SCIENCES INC COM 90328M107   363,314 7,491 SH   DFND 1 7,491 0 0
VEECO INSTRS INC DEL COM 922417100   436,178 12,402 SH   DFND 1 12,402 0 0
VEEVA SYS INC CL A COM 922475108   271,541 1,172 SH   DFND 1 1,172 0 0
VENTYX BIOSCIENCES INC COM 92332V107   19,481,000 3,542,000 SH   DFND 1 3,542,000 0 0
VERA THERAPEUTICS INC CL A 92337R101   440,169 10,208 SH   DFND 1 10,208 0 0
VERACYTE INC COM 92337F107   221,844 10,011 SH   DFND 1 10,011 0 0
VERASTEM INC COM NEW 92337C203   18,153,840 1,538,461 SH   DFND 1 1,538,461 0 0
VERISK ANALYTICS INC COM 92345Y106   593,332 2,517 SH   DFND 1 2,517 0 0
VERVE THERAPEUTICS INC COM 92539P101   152,773 11,504 SH   DFND 1 11,504 0 0
VIATRIS INC COM 92556V106   255,456,921 21,395,052 SH   DFND 1 21,395,052 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   3,342,861 980,311 SH   DFND 1 980,311 0 0
VIKING THERAPEUTICS INC COM 92686J106   38,007,082 463,501 SH   DFND 1 463,501 0 0
VISA INC COM CL A 92826C839   596,394 2,137 SH   DFND 1 2,137 0 0
VISTEON CORP COM NEW 92839U206   247,922 2,108 SH   DFND 1 2,108 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   297,967 32,005 SH   DFND 1 32,005 0 0
WALMART INC COM 931142103   339,178 5,637 SH   DFND 1 5,637 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104   413,331 47,346 SH   DFND 1 47,346 0 0
WARRIOR MET COAL INC COM 93627C101   218,520 3,600 SH   DFND 1 3,600 0 0
WAYFAIR INC CL A 94419L101   427,372 6,296 SH   DFND 1 6,296 0 0
WEAVE COMMUNICATIONS INC COM 94724R108   137,634 11,989 SH   DFND 1 11,989 0 0
WHIRLPOOL CORP COM 963320106   735,366 6,147 SH   DFND 1 6,147 0 0
WINDTREE THERAPEUTICS INC COM NEW 97382D402   215,328 608,272 SH   DFND 1 608,272 0 0
WOODWARD INC COM 980745103   225,478 1,463 SH   DFND 1 1,463 0 0
WW INTL INC COM 98262P101   26,916 14,549 SH   DFND 1 14,549 0 0
XENCOR INC COM 98401F105   419,762 18,968 SH   DFND 1 18,968 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103   162,590 73,570 SH   DFND 1 73,570 0 0
XEROX HOLDINGS CORP COM NEW 98421M106   207,765 11,607 SH   DFND 1 11,607 0 0
ZIFF DAVIS INC COM 48123V102   481,436 7,637 SH   DFND 1 7,637 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   526,864 3,992 SH   DFND 1 3,992 0 0
ZOETIS INC CL A 98978V103   708,821 4,189 SH   DFND 1 4,189 0 0