CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Operating Activities
Net income (loss)	$ (75,738)	$ 131,762	$ 43,313
Adjustments for non-cash items:
Non-cash interest expense on PDL liability		14,646	4,488
Non-cash PDL royalty revenue		(242,808)	(18,104)
Depreciation and amortization	85,737	12,025	6,161
Amortization of investments	358	288	783
Gain on bargain purchase			(484)
Provision for inventory obsolescence	224		347
Loss on disposal of property and equipment	38	19
Stock-based compensation	14,228	8,930	6,109
Change in fair value of contingent consideration and unfavorable contract	(2,625)	2,791	909
Accretion of debt discount	15,629	4,200
Deferred income tax provision (benefit)	(44,166)	87,378	(103,202)
Cash paid for in-process research and development	25,000
Excess tax benefit from stock-based compensation	(4,625)	(3,190)	347
Changes in assets and liabilities:
Accounts receivable	(44,117)	(15,453)	(7,838)
Receivables from collaborative partners	508	10,170	(726)
Inventories	9,329	1,689	4,266
Prepaid and other assets	6,085	(2,190)	1,540
Income taxes receivable	(2,332)	(4,030)
Accounts payable and other accrued liabilities	53,073	(4,750)	7,348
Accrued rebates, returns and discounts	85,348	17,143	3,485
Interest payable	15,992	2,683
Accrued compensation	5,946	171	2,063
Income taxes payable		(61,875)	62,222
Deferred revenue		(15,516)	(3,273)
Net cash (used in) provided by operating activities	143,892	(55,917)	9,754
Investing Activities
Purchases of property and equipment	(1,715)	(599)	(1,812)
Acquisition of business	(1,050,011)		(52,725)
Acquisition of in-process research and development	(25,000)
Acquisition of patents			(150)
Purchases of marketable securities	(116,209)	(73,754)	(37,746)
Maturities of marketable securities	84,884	27,046	53,056
Sales of marketable securities			1,341
Net cash (used in) provided by investing activities	(1,108,051)	(47,307)	(38,036)
Financing Activities
Proceeds from issuance of convertible debt		345,000
Proceeds from the issuance of Senior Notes	562,063
Proceeds from sale of future royalties and milestones to PDL			240,500
Proceeds from issuance of common stock	10,398	9,803	3,727
Excess tax benefit from stock-based compensation	4,625	3,190	(347)
Net cash provided by financing activities	576,575	347,218	243,880
Net increase in cash and cash equivalents	(387,584)	243,994	215,598
Cash and cash equivalents at beginning of year	488,668	244,674	29,076
Cash and cash equivalents at end of year	101,084	488,668	244,674
Supplemental Disclosure of Cash Flow Information
Net cash (received) paid for income taxes	(4,048)	58,318	$ 45
Cash paid for interest	39,511
Non-cash consideration for in-process research and development	29,900
Convertible debt
Financing Activities
Debt issuance costs		$ (10,775)
Senior Notes
Financing Activities
Debt issuance costs	$ (511)