CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Operating Activities
Net income (loss)	$ 131,762us-gaap_NetIncomeLoss	$ 43,313us-gaap_NetIncomeLoss	$ (29,781)us-gaap_NetIncomeLoss
Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities:
Non-cash interest expense on PDL liability	14,646	4,488
Non-cash PDL royalty revenue	(242,808)	(18,104)
Depreciation and amortization	12,025	6,161	2,561
Amortization of investments	288	783	331
Gain on bargain purchase		(484)	(92)
Provision for inventory obsolescence		347us-gaap_InventoryWriteDown	584us-gaap_InventoryWriteDown
Loss on disposal of property and equipment	19		28
Stock-based compensation	8,930us-gaap_ShareBasedCompensation	6,109us-gaap_ShareBasedCompensation	5,070us-gaap_ShareBasedCompensation
Change in fair value of contingent consideration and unfavorable contract	2,791	909
Accretion of debt discount	4,200
Deferred income tax provision (benefit)	87,378	(103,202)
Excess tax benefit from stock-based compensation	(3,190)	347
Changes in assets and liabilities:
Accounts receivable	(15,453)	(7,838)	807
Receivables from collaborative partners	10,170	(726)	(1,943)
Inventories	1,689us-gaap_IncreaseDecreaseInInventories	4,266us-gaap_IncreaseDecreaseInInventories	(2,346)us-gaap_IncreaseDecreaseInInventories
Prepaid and other assets	(2,190)	1,540	(1,509)
Income taxes receivable	(4,030)
Accounts payable and other accrued liabilities	15,076	10,833	5,661
Accrued compensation	171	2,063	1,780
Income taxes payable	(61,875)	62,222
Deferred revenue	(15,516)	(3,273)	(12,136)
Net cash (used in) provided by operating activities	(55,917)	9,754	(30,985)
Investing Activities
Purchases of property and equipment	(599)	(1,812)	(6,880)
Acquisition of business		(52,725)	(26,435)
Acquisition of patents		(150)
Purchases of marketable securities	(73,754)	(37,746)	(38,462)
Maturities of marketable securities	27,046	53,056	61,405
Sales of marketable securities		1,341	43,704
Net cash (used in) provided by investing activities	(47,307)	(38,036)	33,332
Financing Activities
Proceeds from issuance of convertible debt	345,000us-gaap_ProceedsFromConvertibleDebt
Convertible debt issuance costs	(10,775)us-gaap_PaymentsOfDebtIssuanceCosts
Proceeds from sale of future royalties and milestones to PDL		240,500
Proceeds from issuance of common stock	9,803	3,727	2,686
Excess tax benefit from stock-based compensation	3,190	(347)
Net cash provided by financing activities	347,218	243,880	2,686
Net increase in cash and cash equivalents	243,994	215,598	5,033
Cash and cash equivalents at beginning of year	244,674	29,076	24,043
Cash and cash equivalents at end of year	488,668	244,674	29,076
Cash paid during the period for:
Taxes, net of refunds	$ 58,318us-gaap_IncomeTaxesPaidNet	$ 45us-gaap_IncomeTaxesPaidNet	$ 144us-gaap_IncomeTaxesPaidNet

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