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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Revenues:      
Product sales $ 114,219us-gaap_SalesRevenueGoodsNet $ 58,302us-gaap_SalesRevenueGoodsNet $ 27,483us-gaap_SalesRevenueGoodsNet
Royalties 1,821us-gaap_RoyaltyRevenue 45,003us-gaap_RoyaltyRevenue 44,535us-gaap_RoyaltyRevenue
License and other revenue 31,515us-gaap_LicenseAndServicesRevenue 12,796us-gaap_LicenseAndServicesRevenue 18,798us-gaap_LicenseAndServicesRevenue
Non-cash PDL royalty revenue 242,808depo_NonCashRoyaltyRevenueFromSaleOfFutureRoyalties 18,104depo_NonCashRoyaltyRevenueFromSaleOfFutureRoyalties  
Total revenues 390,363us-gaap_Revenues 134,205us-gaap_Revenues 90,816us-gaap_Revenues
Costs and expenses:      
Cost of sales 15,146us-gaap_CostOfGoodsSold 7,091us-gaap_CostOfGoodsSold 6,039us-gaap_CostOfGoodsSold
Research and development expense 7,116us-gaap_ResearchAndDevelopmentExpense 8,073us-gaap_ResearchAndDevelopmentExpense 15,462us-gaap_ResearchAndDevelopmentExpense
Selling, General and Administrative Expense 121,126us-gaap_SellingGeneralAndAdministrativeExpense 105,176us-gaap_SellingGeneralAndAdministrativeExpense 97,646us-gaap_SellingGeneralAndAdministrativeExpense
Amortization of intangible assets 10,161us-gaap_AmortizationOfIntangibleAssets 4,548us-gaap_AmortizationOfIntangibleAssets 2,022us-gaap_AmortizationOfIntangibleAssets
Total costs and expenses 153,549us-gaap_CostsAndExpenses 124,888us-gaap_CostsAndExpenses 121,169us-gaap_CostsAndExpenses
Income (loss) from operations 236,814us-gaap_OperatingIncomeLoss 9,317us-gaap_OperatingIncomeLoss (30,353)us-gaap_OperatingIncomeLoss
Other (expense) income:      
Interest and other income 215us-gaap_InvestmentIncomeNonoperating 662us-gaap_InvestmentIncomeNonoperating 520us-gaap_InvestmentIncomeNonoperating
Interest expense (9,275)us-gaap_InterestExpense (911)us-gaap_InterestExpense (39)us-gaap_InterestExpense
Non-cash interest expense on PDL liability (14,646)depo_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties (4,488)depo_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties  
Total other (expense) income (23,706)us-gaap_NonoperatingIncomeExpense (4,737)us-gaap_NonoperatingIncomeExpense 481us-gaap_NonoperatingIncomeExpense
Net income (loss) before income taxes 213,108us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest 4,580us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest (29,872)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
(Provision for) benefit from income taxes (81,346)us-gaap_IncomeTaxExpenseBenefit 38,733us-gaap_IncomeTaxExpenseBenefit 91us-gaap_IncomeTaxExpenseBenefit
Net income (loss) $ 131,762us-gaap_NetIncomeLoss $ 43,313us-gaap_NetIncomeLoss $ (29,781)us-gaap_NetIncomeLoss
Basic net income (loss) per share (in dollars per share) $ 2.26us-gaap_EarningsPerShareBasic $ 0.76us-gaap_EarningsPerShareBasic $ (0.53)us-gaap_EarningsPerShareBasic
Diluted net income (loss) per share (in dollars per share) $ 2.05us-gaap_EarningsPerShareDiluted $ 0.75us-gaap_EarningsPerShareDiluted $ (0.53)us-gaap_EarningsPerShareDiluted
Shares used in computing basic net income (loss) per share (in shares) 58,292,633us-gaap_WeightedAverageNumberOfSharesOutstandingBasic 56,736,009us-gaap_WeightedAverageNumberOfSharesOutstandingBasic 55,892,563us-gaap_WeightedAverageNumberOfSharesOutstandingBasic
Shares used in computing diluted net income (loss) per share (in shares) 66,307,364us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding 57,543,979us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding 55,892,563us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding