CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Operating Activities
Net income (loss)	$ 43,313	$ (29,781)	$ 70,726
Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities:
Non-cash interest expense on liability related to PDL Transaction	4,488
Non-cash royalty revenue related to PDL Transaction	(18,104)
Depreciation and amortization	6,161	2,561	399
Amortization of investments	783	331	21
Gain on bargain purchase	(484)	(92)
Allowance for inventory obsolescence	347	584	(809)
Loss on disposal of property and equipment		28
Stock-based compensation	6,109	5,070	3,869
Contingent consideration fair value adjustment	909
Deferred income tax benefit	(103,202)
Excess tax benefit from stock-based compensation	347
Changes in assets and liabilities:
Accounts receivable	(7,838)	807	1,673
Receivables from collaborative partners	(726)	(1,943)	(7,881)
Inventories	4,266	(2,346)	(3,016)
Prepaid and other assets	1,540	(1,509)	(4,031)
Accounts payable and other accrued liabilities	10,833	5,661	7,811
Accrued compensation	2,063	1,780	597
Income taxes payable	62,222
Deferred revenue	(3,273)	(12,136)	(11,708)
Net cash provided by (used in) operating activities	9,754	(30,985)	57,651
Investing Activities
Purchases of property and equipment	(1,812)	(6,880)	(698)
Acquisition of business	(52,725)	(26,435)
Acquisition of patents	(150)
Purchases of marketable securities	(37,746)	(38,462)	(195,162)
Maturities of marketable securities	53,056	61,405	58,495
Sales of marketable securities	1,341	43,704	75,177
Net cash (used in) provided by investing activities	(38,036)	33,332	(62,188)
Financing Activities
Proceeds from sale of future royalties to PDL	240,500
Principal payments on long-term debt			(2,244)
Proceeds from issuance of common stock	3,727	2,686	8,298
Excess tax benefit from stock-based compensation	(347)
Net cash provided by financing activities	243,880	2,686	6,054
Net increase (decrease) in cash and cash equivalents	215,598	5,033	1,517
Cash and cash equivalents at beginning of year	29,076	24,043	22,526
Cash and cash equivalents at end of year	244,674	29,076	24,043
Cash paid during the period for:
Interest			133
Taxes	$ 45	$ 144