CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Operating Activities
Net income (loss)	$ 36,908	$ (102,496)	$ (88,720)
Adjustments for non-cash items:
Depreciation and amortization	106,426	105,502	109,375
Accretion of debt discount and debt issuance costs	21,877	19,415	17,673
Loss on prepayment of Senior Notes	0	5,938	5,777
Provision for inventory obsolescence	598	2,673	1,179
(Gain) loss on disposal of property and equipment	669	(271)	0
Stock-based compensation	12,585	13,016	17,172
Change in fair value of contingent consideration	(391)	(8,024)	1,637
Deferred income taxes	0	0	23,632
Gain on divestiture of Lazanda	0	(17,064)	0
Acquired in-process research and development	0	24,900	0
Other	1,023	240	611
Changes in assets and liabilities:
Accounts receivable	35,271	30,107	(30,902)
Inventories	9,048	(1,873)	(3,718)
Prepaid and other assets	(56,136)	(5,114)	(2,464)
Income taxes receivable	0	0	6,359
Accounts payable and other accrued liabilities	(33,610)	(6,436)	5,862
Accrued rebates, returns and discounts	(60,069)	4,292	10,478
Interest payable	(1,576)	(2,705)	(2,747)
Income taxes payable	(126)	67	59
Net cash provided by operating activities	72,497	62,167	71,263
Investing Activities
Purchases of property and equipment	(5,507)	(666)	(2,860)
Investment in convertible instrument	(3,000)	0	0
Proceeds from disposal of property and equipment	145	280	0
Purchases of marketable securities	0	(8,277)	(68,818)
Proceeds from sale of other assets	80	66,557	115,207
Sales of marketable securities	1,200	0	2,007
Net cash provided (used in) by investing activities	(7,082)	57,894	45,536
Financing Activities
Payment of contingent consideration liability	(184)	(1,673)	(1,783)
Repayment of Senior Notes	(82,500)	(110,000)	(100,000)
Fees for early repayment and modifications of Senior Notes	0	(7,400)	(5,000)
Proceeds from issuance of common stock	2,020	8,940	9,951
Shares withheld for payment of employee's withholding tax liability	(686)	(753)	(3,342)
Net cash (used in) financing activities	(81,350)	(110,886)	(100,174)
Net increase (decrease) in cash and cash equivalents	(15,935)	9,175	16,625
Cash and cash equivalents at beginning of year	126,884	117,709	101,084
Cash and cash equivalents at end of period	110,949	126,884	117,709
Supplemental Disclosure of Cash Flow Information
Net cash paid for income taxes	6,472	121
Net cash received for income taxes			(14,425)
Cash paid for interest	48,440	55,542	71,093
Non-cash consideration for in-process research and development	0	19,900	0
Accrued research and development	0	5,000	0
Capital expenditures incurred but not yet paid	$ 212	$ 0	$ 402