Cash And Cash Equivalents, Short-Term Investments, Long-Term Investments And Other Investments (Tables)

9 Months Ended

Sep. 30, 2011

Cash And Cash Equivalents, Short-Term Investments, Long-Term Investments And Other Investments

Cash And Cash Equivalents, Short-Term Investments, Long-Term Investments And Other Investments

	Cash and Cash Equivalents		Short-term Investments		Long-term Investments		Other Investments		Unrealized Gains		Unrealized Losses
As of December 31, 2010
Cash	$	246,843
Money market funds		232,731
Auction rate securities					$	78,747					$	14,203
Municipal debt securities			$	32,707					$	122		24
Corporate debt securities – FDIC insured				9,160						105		1
Treasury securities				38,109						118		2
Equity method investment:
Celtic Therapeutics Holdings, L.P.							$	30,724
Cost method investments:
Bay City Capital Funds								7,069
A.M. Pappas Funds								3,486
Liquidia Technologies, Inc.								5,000
Other investments								1,554
Total	$	479,574	$	79,976	$	78,747	$	47,833	$	345	$	14,230
As of September 30, 2011
Cash	$	197,077
Money market funds		210,759
Certificates of deposit		8,910
Auction rate securities			$	50,374
Asset-backed securities				13,206
Equity method investments:
Celtic Therapeutics Holdings, L.P.							$	58,347
venBio Global Strategic Fund, L.P.								200
Cost method investments:
Bay City Capital Funds								8,751
A.M. Pappas Funds								3,546
Liquidia Technologies, Inc.								5,000
Other investments								1,733
Total	$	416,746	$	63,580	$	—	$	77,577	$	—	$	—

Gross Realized Gains And Losses On Investments

	Three Months Ended September 30,				Nine Months Ended September 30,
	2010		2011		2010		2011
Gross realized gains on short-term investments	$	—	$	—	$	4	$	422
Gross realized gains on cost method investments		—		—		3,340		244
Gross realized losses on short-term investments		—		—		53		5
Gross realized losses on long-term investments		—		—		—		842
Gross realized losses on cost method investments		—		—		750		924

The Company's Capital Commitments

Fund	Ownership			Total Capital Commitment		Remaining Commitment		Commitment Expiration
Bay City Capital Fund IV, L.P.		2.9	%	$	10,000	$	705	September  2010(2)
Bay City Capital Fund V, L.P.		2.0	%		10,000		5,552	October 2012
A.M. Pappas Life Science Ventures III, L.P.		4.7	%		4,750		594	December  2009(2)
A.M. Pappas Life Science Ventures IV, L.P.		3.0	%		2,935		1,702	February 2014
Accelerator III and incubator companies(1)		19.9	%		4,802		819	None

⁽¹⁾  The Company's percentage ownership of Accelerator III and incubator companies might vary but will not exceed 19.9%.

⁽²⁾  The funding commitments to Bay City Capital Fund IV, L.P. and A.M. Pappas Life Science Ventures III, L.P. have expired for new investments. The Company may still be required to fund additional investments in existing fund portfolio companies and the ongoing operations of these funds up to the amount of the remaining capital commitment.