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Condensed Consolidated Statements of Stockholders’ (Deficit) Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
Accumulated Deficit [Member]
Balance at beginning (in shares) at Dec. 31, 2017   73,181,750   41,309  
Balance at beginning at Dec. 31, 2017 $ 66,993 $ 73 $ 422,017 $ (234) $ (354,863)
Issuance of restricted stock (in shares)   87,500      
Forfeiture of restricted stock (in shares)   (123,911)      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) (in shares)   3,989,344      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) 52,430 $ 4 52,426    
Compensation in respect of restricted stock granted to employees, directors and consultants 7,337   7,337    
Net loss (41,529)       (41,529)
Balance at ending (in shares) at Mar. 31, 2018   77,134,683   41,309  
Balance at ending at Mar. 31, 2018 85,232 $ 77 481,781 $ (234) (396,392)
Balance at beginning (in shares) at Dec. 31, 2017   73,181,750   41,309  
Balance at beginning at Dec. 31, 2017 66,993 $ 73 422,017 $ (234) (354,863)
Net loss (119,622)        
Balance at ending (in shares) at Sep. 30, 2018   82,973,332   41,309  
Balance at ending at Sep. 30, 2018 $ 71,744 $ 83 546,380 $ (234) 474,485
Shares issued in connection with in-licensing agreements (in shares) 0        
Balance at beginning (in shares) at Mar. 31, 2018   77,134,683   41,309  
Balance at beginning at Mar. 31, 2018 $ 85,232 $ 77 481,781 $ (234) (396,392)
Issuance of restricted stock (in shares)   1,333,011      
Forfeiture of restricted stock (in shares)   (6,750)      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) (in shares)   3,744,605      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) 52,022 $ 4 52,018    
Compensation in respect of restricted stock granted to employees, directors and consultants 4,264   4,264    
Net loss (44,142)       (44,142)
Balance at ending (in shares) at Jun. 30, 2018   82,539,417   41,309  
Balance at ending at Jun. 30, 2018 101,376 $ 82 542,062 $ (234) 440,534
Issuance of restricted stock   $ 1 (1)    
Shares issued in connection with in-licensing agreements (in shares)   333,868      
Shares issued in connection with in-licensing agreements 4,000   4,000    
Issuance of restricted stock (in shares)   100,700      
Forfeiture of restricted stock (in shares)   (24,785,000)      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) (in shares)   358,000      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) 4,492   4,492    
Compensation in respect of restricted stock granted to employees, directors and consultants (173)   (173)    
Net loss (33,951)       (33,951)
Balance at ending (in shares) at Sep. 30, 2018   82,973,332   41,309  
Balance at ending at Sep. 30, 2018 71,744 $ 83 546,380 $ (234) 474,485
Balance at beginning (in shares) at Dec. 31, 2018   83,911,855   41,309  
Balance at beginning at Dec. 31, 2018 24,036 $ 84 552,531 $ (234) 528,345
Issuance of restricted stock (in shares)   23,000      
Forfeiture of restricted stock (in shares)   (67,628)      
Compensation in respect of restricted stock granted to employees, directors and consultants 1,882   1,882    
Net loss (35,156)       (35,156)
Balance at ending (in shares) at Mar. 31, 2019   88,582,227   41,309  
Balance at ending at Mar. 31, 2019 19,254 $ 89 582,900 $ (234) 563,501
Warrants issued with debt financing 993   993    
Issuance of common stock in public offering (net of offering costs of $0.2 million) (in shares)   4,715,000      
Issuance of common stock in public offering (net of offering costs of $0.2 million) 27,499 $ 5 27,494    
Balance at beginning (in shares) at Dec. 31, 2018   83,911,855   41,309  
Balance at beginning at Dec. 31, 2018 24,036 $ 84 552,531 $ (234) 528,345
Net loss (133,299)        
Balance at ending (in shares) at Sep. 30, 2019   96,670,197   41,309  
Balance at ending at Sep. 30, 2019 (25,791) $ 97 635,989 $ (234) 661,643
Shares issued in connection with in-licensing agreements 100        
Balance at beginning (in shares) at Mar. 31, 2019   88,582,227   41,309  
Balance at beginning at Mar. 31, 2019 19,254 $ 89 582,900 $ (234) 563,501
Issuance of restricted stock (in shares)   1,245,080      
Forfeiture of restricted stock (in shares)   (38,418)      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) (in shares)   3,616,359      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) 28,395 $ 3 28,392    
Compensation in respect of restricted stock granted to employees, directors and consultants 1,757   1,757    
Net loss (36,212)       (36,212)
Balance at ending (in shares) at Jun. 30, 2019   93,405,248   41,309  
Balance at ending at Jun. 30, 2019 13,205 $ 93 613,059 $ (234) 599,713
Issuance of restricted stock   $ 1 (1)    
Issuance of common stock in public offering 11   11    
Issuance of restricted stock (in shares)   318,440      
Forfeiture of restricted stock (in shares)   (5,334)      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) (in shares)   2,943,460      
Issuance of common stock in At-the-Market offerings (net of offering costs of $0.9 million) 20,759 $ 4 20,755    
Compensation in respect of restricted stock granted to employees, directors and consultants 2,075   2,075    
Net loss (61,930)       (61,930)
Balance at ending (in shares) at Sep. 30, 2019   96,670,197   41,309  
Balance at ending at Sep. 30, 2019 (25,791) $ 97 635,989 $ (234) $ 661,643
Shares issued in connection with in-licensing agreements (in shares)   8,383      
Shares issued in connection with in-licensing agreements $ 100   $ 100