Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) shares in Thousands, $ in Thousands	6 Months Ended
Jun. 30, 2019	Jun. 30, 2018
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ 71,368	$ 85,671
Adjustments to reconcile net loss to net cash used in operating activities:
Total	3,639	11,601
Noncash licensing expense	100	4,000
Depreciation	46	41
Amortization of premium on investment securities	(149)	(9)
Amortization of debt issuance costs	308	0
Non-cash change in lease liability and right-of-use asset	902	0
Change in fair value of notes payable and accrued interest	78	82
Change in fair value of notes payable and accrued interest	(78)	(82)
Changes in assets and liabilities:
Decrease (increase) in prepaid research and development and other current assets	663	(1,213)
Decrease in leasehold interest	(91)	(53)
(Increase) decrease in accrued interest receivable	(10)	(22)
(Decrease) increase in accounts payable and accrued expenses	(5,588)	8,898
Decrease in lease liability	(678)	0
Increase in interest payable	443	0
Increase in other current liabilities	2,388	0
Increase in deferred rent	0	46
Decrease in deferred revenue	(76)	(76)
Net cash used in operating activities	(69,211)	(62,226)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of equipment	(32)	(58)
Investment in held-to-maturity securities	(14,146)	(6,965)
Proceeds from maturity of short-term securities	13,500	14,400
Net cash (used in) provided by investing activities	(678)	7,377
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from sale of common stock, net	55,965	104,453
Proceeds from debt financings	29,679	0
Financing costs paid	(480)	0
Net cash provided by financing activities	85,164	104,453
NET INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	15,275	49,604
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF PERIOD	43,199	57,305
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF PERIOD	58,474	106,909
Reconciliation to amounts on consolidated balance sheets:
Total cash, cash equivalents and restricted cash	43,199	57,305
NONCASH TRANSACTIONS
Accrued offering costs	60	0
Deferred financing costs	988	$ 0
Warrants issued with debt financing	$ 993
Shares issued in connection with in-licensing agreements	100

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