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Consolidated Statements of Operations - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Statement [Abstract]      
License revenue $ 152,381 $ 152,381 $ 152,381
Research and development:      
Noncash compensation 5,646,716 2,742,354 4,261,406
Other research and development 96,886,134 66,489,820 43,445,817
Total research and development 102,532,850 69,232,174 47,707,223
General and administrative:      
Noncash compensation 10,298,568 4,767,645 11,435,686
Other general and administrative 6,032,714 5,121,690 4,189,488
Total general and administrative 16,331,282 9,889,335 15,625,174
Total costs and expenses 118,864,132 79,121,509 63,332,397
Operating loss (118,711,751) (78,969,128) (63,180,016)
Other (income) expense:      
Interest income (294,478) (323,032) (174,653)
Other (income) expense 58,739 (393,202) (56,717)
Total other income, net (235,739) (716,234) (231,370)
Net loss $ (118,476,012) $ (78,252,894) $ (62,948,646)
Basic and diluted net loss per common share (in dollars per share) $ (1.91) $ (1.60) $ (1.38)
Weighted average shares used in computing basic and diluted net loss per common share (in shares) 62,069,570 49,041,354 45,646,414