ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Accounting Policies [Abstract]
Accumulated deficit	$ (354,862,832)	$ (236,386,820)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	4,835,706	8,033,779	7,064,396
Restricted Cash and Investments	$ 600,000	$ 600,000
Prepaid Manufacturing	$ 8,100,000	$ 5,700,000