Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (348,101)	$ (279,381)	$ (172,871)
Adjustments to reconcile net loss to net cash used in operating activities:
Noncash stock compensation expense	61,274	80,289	11,335
Shares issued in connection with in-licensing agreement	0	0	100
Depreciation and amortization	282	158	100
Amortization of premium on investment securities	517
Amortization of premium on investment securities		(30)	(257)
Amortization of debt issuance costs	1,080	925	772
Amortization of leasehold interest	212	216	182
Noncash change in lease liability and right of use asset	1,896	2,325	2,519
Change in fair value of notes payable	(578)	748	124
Changes in assets and liabilities:
(Increase) decrease in other current assets	(8,508)	2,257	1,384
Increase in accounts receivable	(1,389)	0	0
Increase (decrease) in accounts payable and accrued expenses	15,991	11,631	(4,795)
(Decrease) increase in lease liabilities	(2,012)	(1,988)	(1,548)
Decrease (increase) in other liabilities	(16,146)	(31,505)	30,301
Decrease in deferred revenue	(152)	(152)	(152)
Net cash used in operating activities	(295,634)	(214,507)	(132,806)
CASH FLOWS FROM INVESTING ACTIVITIES
Proceeds from maturity of short-term securities	55,600	43,250	29,250
Investment in held-to-maturity securities	(55,531)	(67,403)	(29,837)
Purchases of equipment	(401)	(357)	(131)
Net cash (used in) provided by investing activities	(332)	(24,510)	(718)
CASH FLOWS FROM FINANCING ACTIVITIES
Payment of loan payable	(30,000)	0	0
Proceeds from sale of common stock, net	2,219	679,680	175,021
Proceeds from exercise of options	216	147	0
Proceeds from debt financings	70,000	0	29,987
Financing costs paid	(1,016)	0	(795)
Net cash (used in) provided by financing activities	41,419	679,827	204,213
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	(254,547)	440,810	70,689
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF PERIOD	554,698	113,888	43,199
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF PERIOD	$ 300,151	$ 554,698	$ 113,888

The change in fair value of notes payable during the period.

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