INCOME TAXES

12 Months Ended

Dec. 31, 2021

INCOME. TAXES.

INCOME TAXES

NOTE 8 – INCOME TAXES

We account for income taxes under the asset and liability method. Deferred tax assets and liabilities are determined based on differences between the financial reporting and tax basis of assets and liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. A valuation allowance is established when necessary to reduce deferred tax assets to the amount expected to be realized. In determining the need for a valuation allowance, management reviews both positive and negative evidence, including current and historical results of operations, future income projections and the overall prospects of our business. Based upon management's assessment of all available evidence, we believe that it is more-likely-than-not that the deferred tax assets will not be realizable, and therefore, a valuation allowance has been established. The valuation allowance for deferred tax assets was approximately $367.4 million and $276.7 million as of December 31, 2021 and 2020, respectively.

The Coronavirus Aid, Relief, and Economic Security Act of 2020 (“CARES Act”) was enacted on March 27, 2020 in response to the economic fall out of the COVID-19 pandemic in the United States. The CARES Act allows employers to defer the deposit and payment of the employer’s share of Social Security taxes during the payroll tax deferral period of March 27, 2020 through December 31, 2020. The CARES Act provides for half of the deferred payroll taxes to be paid by December 31, 2021 and the second half to be paid by December 31, 2022. The Company did not participate in this deferral program.

As of December 31, 2021, we have U.S. net operating loss carryforwards of approximately $1.3 billion, research and development credit carryforwards (“R&D credits”) of approximately $35.7 million and business interest expense carryforward of $9.8 million. For income tax purposes, these NOLs and R&D credits will expire in various amounts through 2038. NOLs generated after 2017 and the business interest expense carryforwards do not expire. The Tax Reform Act of 1986 contains provisions which limit the ability to utilize net operating loss carryforwards and R&D credit carryforwards in the case of certain events including significant changes in ownership interests. The Exchange Transaction with TG Bio may have resulted in a “change in ownership” as defined by IRC Section 382 of the Internal Revenue Code of 1986, as amended. Additionally, stock issuance activities may have resulted in a “change in ownership” as defined by IRC Section 382 of the Internal Revenue Code of 1986, as amended. Accordingly, a substantial portion of the Company’s NOLs above may be subject to annual limitations in reducing any future year’s taxable income, and a substantial portion of the R&D Credit carryforwards may be subject to annual limitations in reducing any future year’s tax.

The tax effects of temporary differences that give rise to significant portions of the deferred tax assets and deferred tax liabilities at December 31, 2021 and 2020 are presented below.

(in thousands)	2021		2020
Deferred tax assets:
Net operating loss carryforwards	$	295,985	$	223,685
Research and development credit		35,665		27,558
Noncash compensation		32,356		22,381
Disallowed interest		2,434		1,855
Other		1,006		1,224
Deferred tax asset, excluding valuation allowance		367,446		276,703
Less valuation allowance		(367,446)		(276,703)
Net deferred tax assets	$	—	$	—

There was no current or deferred income tax expense for the year ended December 31, 2021. Income tax expense differed from amounts computed by applying the US Federal income tax rate of 21% for the years ending December 31, 2021, 2020 and 2019, to pretax loss as follows:

	For the year ended December 31,
(in thousands)	2021		2020		2019
Loss before income taxes, as reported in the consolidated statements of operations	$	(348,101)	$	(279,381)	$	(172,871)
Computed “expected” tax benefit	$	(73,101)	$	(58,670)	$	(36,303)
Increase (decrease) in income taxes resulting from:
Expected benefit from state and local taxes		(3,445)		(10,801)		(2,128)
Research and development credits		(8,337)		(5,265)		(7,266)
Other		867		1,065		641
Stock options		(6,726)		(1,558)		1,292
Enactment of federal tax reform		—		(14,763)		—
Change in the balance of the valuation allowance for deferred tax assets		90,742		89,992		43,764
	$	—	$	—	$	—

We file income tax returns in the U.S Federal and various state and local jurisdictions. With certain exceptions, the Company is no longer subject to U.S. Federal and state income tax examinations by tax authorities for years prior to 2018. However, NOLs and tax credits generated from those prior years could still be adjusted upon audit.

The Company would recognize interest and penalties, if any, to uncertain tax position in income tax expense in the statement of operations. There was no accrual for interest and penalties related to uncertain tax positions for 2021. We do not believe that there will be a material change in our unrecognized tax positions over the next twelve months. All of the unrecognized tax benefits, if recognized, would be offset by the valuation allowance