CONSOLIDATED STATEMENTS OF STOCKHOLERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive (Loss) Income	Non- Controlling Interest
Beginning Balances (in shares) at Dec. 31, 2019		115,972,708
Beginning Balances at Dec. 31, 2019	$ 432,739	$ 1,160	$ 1,090,828	$ (656,985)	$ (2,449)	$ 185
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)		1,395,956
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ 8,559	$ 14	8,545
Issuance of common stock under employee stock purchase plan (in shares)	274,382	274,382
Issuance of common stock under employee stock purchase plan	$ 2,015	$ 3	2,012
Issuance of common stock, net (in shares)		24,420,157
Issuance of common stock, net	142,526	$ 244	142,282
Stock-based compensation	25,708		25,708
Acquisition of additional shares of Sangamo France	(927)					(927)
Foreign currency translation adjustment	8,345				8,345
Net pension gain (loss)	(193)				(193)
Net unrealized loss on marketable securities, net of tax	(284)				(284)
Buy-out of non-controlling interest	0
Net loss	(121,122)			(120,996)		(126)
Ending Balances (in shares) at Dec. 31, 2020		142,063,203
Ending Balances at Dec. 31, 2020	497,366	$ 1,421	1,269,375	(777,981)	5,419	(868)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)		1,417,288
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ 2,389	$ 14	2,375
Issuance of common stock under employee stock purchase plan (in shares)	433,107	433,107
Issuance of common stock under employee stock purchase plan	$ 3,370	$ 4	3,366
Issuance of common stock, net (in shares)		2,007,932
Issuance of common stock, net	27,099	$ 20	27,079
Stock-based compensation	32,956		32,956
Acquisition of additional shares of Sangamo France	(134)		(70)			(64)
Foreign currency translation adjustment	(8,351)				(8,351)
Net pension gain (loss)	(716)				(716)
Net unrealized loss on marketable securities, net of tax	(339)				(339)
Buy-out of non-controlling interest	943		(943)			943
Net loss	$ (178,297)			(178,286)		(11)
Ending Balances (in shares) at Dec. 31, 2021	145,921,530	145,921,530
Ending Balances at Dec. 31, 2021	$ 375,343	$ 1,459	1,334,138	(956,267)	(3,987)	0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)		994,097
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ (1,980)	$ 10	(1,990)
Issuance of common stock under employee stock purchase plan (in shares)	576,950	576,950
Issuance of common stock under employee stock purchase plan	$ 1,771	$ 6	1,765
Issuance of common stock, net (in shares)		19,300,743
Issuance of common stock, net	84,869	$ 193	84,676
Stock-based compensation	31,650		31,650
Foreign currency translation adjustment	(4,606)				(4,606)
Net pension gain (loss)	786				786
Net unrealized loss on marketable securities, net of tax	(597)				(597)
Buy-out of non-controlling interest	0
Net loss	$ (192,278)			(192,278)
Ending Balances (in shares) at Dec. 31, 2022	166,793,320	166,793,320
Ending Balances at Dec. 31, 2022	$ 294,958	$ 1,668	$ 1,450,239	$ (1,148,545)	$ (8,404)	$ 0