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OTHER BALANCE SHEET DETAILS
 12 Months Ended
Dec. 31, 2022
Balance Sheet Related Disclosures [Abstract]  
OTHER BALANCE SHEET DETAILS OTHER BALANCE SHEET DETAILS
Property and Equipment, Net
Property and equipment, net consist of the following (in thousands):
December 31,
20222021
Laboratory equipment$39,080 $31,988 
Leasehold improvements26,559 21,970 
Furniture and fixtures9,744 9,080 
Manufacturing equipment9,908 8,781 
Construction in progress14,770 4,729 
100,061 76,548 
Less: accumulated depreciation and amortization(36,530)(25,025)
Property and equipment, net$63,531 $51,523 
Depreciation and amortization expense was $12.1 million in 2022, $9.4 million in 2021 and $5.7 million in 2020.
Intangible Assets
The changes in intangible assets were as follows (in thousands):
December 31,
20222021
Balance at beginning of year$53,760 $58,128 
Foreign currency translation adjustment(3,031)(4,368)
Balance at end of year$50,729 $53,760 
Goodwill
The changes in goodwill were as follows (in thousands):
December 31,
20222021
Balance at beginning of year$39,702 $42,798 
Foreign currency translation adjustment(2,150)(3,096)
Balance at end of year$37,552 $39,702 
Other Accrued Liabilities
Other accrued liabilities consist of the following (in thousands):
December 31,
20222021
Accrued research and development expenses$7,115 $4,878 
Operating lease liabilities – current
4,122 4,026 
Accrued professional fees1,704 869 
Other3,066 1,804 
Total other accrued liabilities$16,007 $11,577