CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating Activities:
Net loss	$ (87,150)	$ (93,113)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	5,716	4,120
Amortization of premium on marketable securities	207	1,733
Amortization and other changes in operating lease right-of-use assets	4,225	4,067
Gain on free shares	0	(18)
Stock-based compensation	15,609	17,007
Net changes in operating assets and liabilities:
Interest receivable	60	228
Accounts receivable	11	(1,658)
Prepaid expenses and other assets	(4,992)	(4,441)
Accounts payable and other accrued liabilities	5,796	(3,204)
Accrued compensation and employee benefits	(6,618)	(3,253)
Deferred revenues	(43,772)	(41,481)
Lease liabilities	(2,121)	(2,102)
Other non-current liabilities	69	998
Net cash used in operating activities	(112,960)	(121,117)
Investing Activities:
Purchases of marketable securities	(129,928)	(180,049)
Maturities of marketable securities	168,346	323,099
Sales of marketable securities	0	6,870
Purchases of property and equipment	(8,284)	(15,213)
Purchase of additional Sangamo France shares	0	(119)
Net cash provided by investing activities	30,134	134,588
Financing Activities:
Taxes paid related to net share settlement of equity awards	(1,827)	(2,725)
Proceeds from exercise of stock options	90	3,702
Net cash provided by financing activities	21,307	25,254
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	352	(176)
Net (decrease) increase in cash, cash equivalents, and restricted cash	(61,167)	38,549
Cash, cash equivalents, and restricted cash, beginning of period	180,372	132,829
Cash, cash equivalents, and restricted cash, end of period	119,205	171,378
Supplemental cash flow disclosures:
Property and equipment included in unpaid liabilities	2,232	2,267
Right-of-use assets obtained in exchange for lease obligations	0	1,364
Buy-out of non-controlling interest	0	943
At the Market Offering
Financing Activities:
Proceeds from at-the market offering/ issuance of common stock	21,929	22,223
Employee Stock
Financing Activities:
Proceeds from at-the market offering/ issuance of common stock	$ 1,115	$ 2,054